E-Dissertationen: Search
Now showing items 1-5 of 5
Design, Synthesis and Structure-Activity-Relationships of Potent Mas-Related G Protein-Coupled Receptor X (MRGPRX) Modulators
(2021-04-12)
The G protein-coupled receptor (GPCR) superfamily with more than 800 members is one of the most important target classes for drug development. After an agonist binds to the receptor, it induces a conformational change ......
EBI2 is a negative modulator of adipose tissue activity
(2020-08-17)
Weight-related diseases are common and often fatal conditions characterized by an imbalance between energy intake and energy expenditure. Obesity and weight gain related diseases such as type 2-diabetes have reached in the ...
The role of Sphingosine-1-phosphate receptors in adipocytes and adipose tissues
(2021-01-19)
Obesity is a worldwide health issue with increasing numbers of patients every year. Moreover, the prevalence of obesity gives rise to related cardiovascular diseases and various other comorbidities influencing quality of ...
The role of GPR111 in adipose tissue
(2021-05-21)
Due to obesity pandemic and limited therapeutic approaches, novel targets of pharmaceutical treatments are urgently needed. AT as a very important metabolic organ is an attractive target for combating obesity and obesity ......
G protein coupled receptors require active Gαq to mobilize Gi-Gβγ-dependent calcium
(2021-06-23)
The mechanisms by which GPCRs drive calcium mobilization in living cells have been a topic of intense research interest for many years. One such mechanism is the paradigmatic Gi-calcium pathway, which describes how Gβγ ...