E-Dissertationen: Search
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Identifizierung und Charakterisierung neuartiger Oxidoreduktasen in Gluconobacter oxydans und Produktion des potentiellen Süßstoffes 5-Keto-D-Fruktose
(2018-04-10)
Thema der vorliegenden Arbeit war die Identifizierung und Charakterisierung unbekannter PQQ- und FAD-abhängiger Oxidoreduktasen, deren regiospezifische Umsetzung von Substraten in Hinblick auf die Entwicklung biotechnologischer ......
Molekulare Mechanismen idiosynkratischer Medikamenten-vermittelter Leberschädigung
(2018-04-13)
Idiosynkratischer Medikamenten-induzierter Leberschaden (engl.: idiosyncratic drug induced liver injury, iDILI) stellt ein gravierendes Problem in der Medikamentenentwicklung und der klinischen Erforschung von Medikamenten ...
Metabolites of bacteria isolated from marine environments: chemistry and bioactivities
(2018-04-19)
Roseovarius oyster disease (ROD) is a bacterial-induced infection and causes major problems in oyster aquaculture. Bacteria of the genus Labrenzia have been proposed as protective agents against ROD. The here investigated ...
Functional Characterization of Interaction Partners of the Co-Chaperone BAG3
(2018-04-23)
Protein homeostasis (proteostasis) describes the cellular balance between protein synthesis, function and degradation. The stress inducible co-chaperone BAG3 is a key factor in proteostasis, in particular under mechanical ...
Systematische Identifizierung und Charakterisierung ursächlich genetischer Faktoren seltener urorektaler und gastrointestinaler Fehlbildungen
(2018-07-05)
Urorektale und gastrointestinale Malformationen sind menschliche Entwicklungsdefekte, die sich mit einem breiten phänotypischen Spektrum manifestieren und genetisch sehr heterogen sind. Die Ätiologie ist in den meisten ......
Molecular Mechanisms in the Unconventional Secretion of Insulin-Degrading Enzyme
(2018-04-12)
Extracellular deposition of amyloid-ß (Aß) plaques in the brain, a hallmark of Alzheimer’s disease (AD), results from an imbalance between production and clearance of the peptide. Insulin-degrading enzyme (IDE) is one of ...
Study of infection induced alteration in Drosophila larval feeding behavior
(2018-03-27)
Decision making ability is a key trait that can increase an organism’s chances of survival. The animal has to constantly analyze its environment and modulate ones behavior to navigate through daily routine. This study aims ...
The role of guanine nucleotide exchange factors (GEFs) in EGF-receptor signalling: Screening for a small molecule inhibitor of the Rin1-mediated Rab5 activation
(2018-06-04)
The small GTPase Rab5 is a key regulator of early endosomal trafficking. It functions as a molecular switch that can be activated by guanine nucleotide exchange factors (GEFs) and inactivated via hydrolysis of GTP with the ...
Complement-mediated neuronal loss by sialic acid glycocalyx alterations
(2018-04-23)
Every neuronal cell is covered with a dense structure of glycoconjugates, the glycocalyx. Sialic acids form the terminal ends of the glycocalyx and thus, are more accessible for the cellular environment. Microglia, the ...
Regulation of gene expression in specific mouse brain cells during neurodegenerative prion disease
(2018-05-24)
Why neurodegenerative diseases target specific brain regions is poorly understood. We hypothesize that this selective vulnerability is caused by specific brain cells in these regions having unique strategies and capacities ...