E-Dissertationen: Search
Now showing items 1-10 of 28
The role of Cysteine-rich with EGF-like domains 2 in the maintenance of metabolic homeostasis and regulation of the unfolded protein response
(2019-12-17)
Das Ziel dieser Arbeit war es, die Rolle von Creld2 bei der Aufrechterhaltung der metabolischen Homöostase unter Normalbedingungen und bei der Regulation der UPR unter ER Stressbedingungen zu untersuchen. Metabolische ...
Effects of intracranial stimulation and the involvement of the human parahippocampal cortex in perception
(2019-10-04)
How the human brain translates photons hitting the retina into conscious perception remains an open question. Throughout the medial temporal lobe (MTL), there are neurons (called concept cells) that change their firing ...
Expression and Function of ErbB4 Splice Variants in the Central Nervous System
(2019-07-18)
Neuregulins and their cognate neuronal receptor tyrosine kinase ErbB4 (avian erythroblastosis virus oncogene B4) are genetically linked with an increased risk for schizophrenia. NRG/ErbB4 signaling regulates neurodevelopment, ......
Neureguline und ihr neuronaler Tyrosinkinaserezeptor ErbB4 (avian erythroblastosis virus oncogene B4) sind genetisch mit einem erhöhtem Risiko für Schizophrenie assoziiert. NRG/ErbB4 Signalübertragung reguliert unter anderem ......
Neureguline und ihr neuronaler Tyrosinkinaserezeptor ErbB4 (avian erythroblastosis virus oncogene B4) sind genetisch mit einem erhöhtem Risiko für Schizophrenie assoziiert. NRG/ErbB4 Signalübertragung reguliert unter anderem ......
Pharmacometric approaches for linking pharmacokinetic and pharmacodynamic models of sunitinib and pazopanib with clinical outcome
(2019-07-22)
Aim of this thesis was to build a modeling framework for patients with metastatic renal cell carcinoma (mRCC) treated with two common first-line therapies, sunitinib and pazopanib. Therefore, as part of the European-wide ...
FR900359, an inhibitor of guanine nucleotide dissociation, effectively blunts signaling of GTPase-deficient Gq: mechanism of action and relevance for treating Gq-driven cancers
(2019-08-01)
Uveal melanoma (UM), the most common cancer of the adult eye, is known to have poor prognosis. Over 50% of patients are likely to develop metastasis. In more than 80% of the cases UM is driven by an activating mutation in ...
Impact of ERK signaling and its spatial regulation on cisplatin sensitivity in ovarian cancer cells
(2019-11-08)
The efficiency of the anticancer drug cisplatin in ovarian cancer is often limited by the development of cisplatin resistance. Cisplatin activates a plethora of DNA damage-related signaling pathways, which regulate the ...
Platelet-immune cell interactions in inflammation and cancer
(2019-09-10)
Platelets are well-known for their role in hemostasis and only more recently, they have also been acknowledged for their immune regulatory roles. Despite being small sized and anucleated, they can respond to inflammatory ...
Quantitative proteome analysis of S-nitrosylation on synaptosomal proteins in Alzheimer's disease
(2019-08-28)
Alzheimer's disease (AD) is an irreversible, progressive and most common type of dementia in the aging population. AD pathophysiology starts slowly and deteriorates over time before the clinical diagnosis of dementia can ...
Novel vaccination strategies for CD4+ T cell immunotherapy of melanoma
(2019-09-06)
Immunotherapy has emerged as a standard treatment modality in melanoma and many other cancers. While a lot is known about the anti-tumoral effector functions of CD8+ T cells, CD4+ T cells remain less well understood in ......
Characterization of VKORC1L1 with respect to VKORC1
(2019-07-10)
Vitamin K reduction is essential and catalyzed by two enzymes in vitro. Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) reduces vitamin K to sustain γ-carboxylation of vitamin K dependent (VKD) proteins. This ...