E-Dissertationen: Search
Now showing items 1-10 of 21
Biologicals and Biosimilars: Differences and implementation of the regulatory requirements in the European Union versus those in the United States with special consideration and analysis of the implementation and improvement of safety standards for biosimilar products
(2018-06-08)
What safety relevant standards are established for biotechnology-derived biosimilar products in both the European Union (EU) and the USA? And, is there potential to improve the current safety standards? The applicable ...
Syntheses and structure-activity relationships of novel P2X3 receptor antagonists
(2018-04-19)
P2X3 receptors are ligand-gated ion channels activated by extracellular adenosine-5’-triphosphate (ATP). Activation of the P2X3 receptors has been linked to several pathophysiological conditions including inflammation and ...
Investigation of systemic inflammation in aneurysmal subarachnoid hemorrhage (aSAH) and its impact on post-aSAH complications
(2018-05-23)
Aneurysmal subarachnoid hemorrhage (aSAH) is a dreadful disease with overwhelmingly high mortality and morbidity, although it accounts for only 5% of all strokes. Around half of the affectees are destined to death and it ...
Dry granulation via roller compaction: investigation on scale up strategies integrating process parameters and critical material attributes
(2018-05-23)
Granulation processes for solid oral dosage forms are commonly used in the pharmaceutical industry to enhance the quality of the final product, i.e. tablets. Today, roller compaction is one of the most common granulation ...
Synthesis and biological evaluation of novel ligands for the cannabinoid-like orphan G protein-coupled receptors GPR18 and GPR55
(2018-09-26)
GPR18 and GPR55 belong to the more than 100 orphan G protein-coupled receptors (GPCRs) whose natural signaling molecules remain unidentified. Both orphan GPCRs have some relations with the cannabinoid receptors CB1 ......
Einflüsse gesetzlicher Änderungen auf Medizinprodukteunternehmen: Betrachtung von vertikaler und horizontaler Gesetzgebung unter besonderer Berücksichtigung der Medizinprodukteverordnungen, RoHS und REACH
(2018-06-13)
Medizinprodukte stellen eine sehr heterogene Produktgruppe dar und somit sind gesetzliche Vorgaben umfangreich. Die gesetzlichen Rahmenbedingungen zur Herstellung und zum Inverkehrbringen von Medizinprodukten können ...
Qualität der Kundeninformationen von Herstellern bei korrektiven Maßnahmen zu In-vitro Diagnostika: Analyse der vom BfArM 2005 bis 2014 publizierten Daten
(2018-08-15)
In dieser Arbeit wurden erstmals die gesamten auf der Homepage des BfArM publizierten Kundeninformationen zu korrektiven Maßnahmen bei In-vitro Diagnostika auf Inhalt und Qualität überprüft. Der Vergleich mit den Rote Hand ...
Investigation of Phthalazine, Quinazoline and Pyrimidine Derivatives as ABCG2 Inhibitors
(2018-08-28)
Globally, cancer is the second leading cause of death. Chemotherapy is commonly used in the treatment of cancer. However, in clinic, a wide variety of cancers display resistance to chemotherapy leading to the failure of ...
Entwicklung, Charakterisierung, Analytik und Anwendung von Tracern und Tool-Verbindungen für Gq-Proteine
(2018-10-11)
G-Protein-gekoppelte Rezeptoren (GPCRs), die wichtige Arzneimittelziele sind, aktivieren intrazelluläre G-Proteine, die als Relais zur Steuerung intrazellulärer Signalwege dienen. Die Blockade von Gq-Proteinen könnte eine ...
Activity patterns in the septal-hippocampal network predict voluntary locomotion
(2018-07-13)
In the brain of animals, locomotion is encoded and represented in multiple ways. During locomotion, the hippocampus (HC) displays characteristic activity patterns that change from asynchronous states when the animal is ...