E-Dissertationen: Suche
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The role of guanine nucleotide exchange factors in the regulation of immune cell signaling
(2009-07-08)
The ARF GEF cytohesin-1 was originally identified as β2-integrin binding protein, and was shown to play an important role in the control of integrin-dependent immune cell migration and adhesion via activating the small ...
Langerhans and inflammatory dendritic epidermal cells in atopic dermatitis tolerate Toll-like receptor 2-specific activation
(2021-01-26)
Atopic dermatitis (AD) is a chronic multifactorial inflammatory skin disease. The skin of AD patients shows a significant dysbalance of the microbiome with high colonization of S. aureus, which positively correlates with ...
The response of human myeloid cells to the infection with Listeria monocytogenes
(2013-05-22)
Macrophages and dendritic cells (DC) constitute the first line of defense against invading microorganisms. These myeloid cells have been identified as the major components of the outer ringwall of suppurative granulomas ......
Hemmung des GM2-Gangliosid Metabolismus in, aus humanen Monozyten generierten, Dendritischen Zellen
(2015-07-06)
Seitdem man Ende der 80er Jahre mit der Verwendung von dendritischen Zellen in der immuntherapeutischen Behandlung von Krebs begann, wurden in klinischen Studien bereits einige Fortschritte, die zu einer verbesserten ...
Impact of the lack of cross-presenting dendritic cells on the generation of inflammatory immune responses in experimental Plasmodium berghei ANKA infection and therapeutic possibilities to limit excessive brain inflammation with doxycycline
(2017-07-21)
Malaria is a vector-transmitted disease caused by unicellular parasites of the Plasmodium species and resulted in over 400,000 deaths in 2015, most of them in African children below the age of five. Plasmodium parasites ......
Recognition of cytosolic 3´P DNA & The role of GCET2+ DCs in cross-presentation
(2020-04-01)
In mammalian cells, DNA is confined to the nucleus and mitochondria. Detection of DNA in other compartments like the cytoplasm indicates danger and infection. Our research group has previously discovered that 3´monophosphate ...
Functional roles of the chemokine CCL17 in skin and brain immunity
(2019-02-04)
The chemokines CCL17 and CCL22 represent ligands of CCR4 and are mainly produced by dendritic cells (DCs) and macrophages (Mφs) in the immune system. CCL17 was found to promote various inflammatory and allergic diseases, ......
Funktionen des Chemokins CCL17 im Immunsystem der Haut und des Gehirns
Die Chemokine CCL17 und CCL22 sind Liganden von CCR4 und werden hauptsächlich von dendritischen Zellen (DCs) und Makrophagen ......
Funktionen des Chemokins CCL17 im Immunsystem der Haut und des Gehirns
Die Chemokine CCL17 und CCL22 sind Liganden von CCR4 und werden hauptsächlich von dendritischen Zellen (DCs) und Makrophagen ......
Elucidation of multinumerous centrosomes and their impact on migration in dendritic cells
(2023)
Centrosomes act as major microtubule organizing center (MTOC) in most animal cells and are well known for their role in building up the mitotic spindle during cell division. Core structure of the centrosome are two tubulus ...