E-Dissertationen: Search
Now showing items 1-6 of 6
Identification, optimization and characterization of pharmacological tools for the cannabinoidactivated orphan G protein-coupled receptor GPR18 and related receptors
(2017-12-21)
Cannabinoid receptors comprise two classical subtypes, CB1 and CB2, which belong to the large family of G protein-coupled receptors (GPCRs). They are the major targets of cannabinoids such as ......
Purines and 9-deazapurines as Modulators of Multidrug Resistance-associated Protein 1 (MRP1/ABCC1)-mediated Transport
(2017-11-14)
Expression of ABC-transport proteins is a major obstacle in cancer chemotherapy. Especially MRP1, P-gp and BCRP are expressed in different malignancies like lung cancer, colon carcinomas, leukemias, bladder cancer, myeloma, ...
Influence of the Conformation of Conotoxins on their Bioactivity
(2017-12-14)
In the last decade peptides filled the gap between small molecule drugs and biologics as therapeutics. A rich source of such peptides represents the venom of different animals evolved over millions of years. Conotoxins are ...
Synthese und Untersuchung neuer ABCG2 Inhibitoren
(2017-03-29)
Aufgrund dessen, dass die Überexpression von ABCG2 eine Rolle bei der Entstehung der Multidrug Resistance von Krebszellen spielt wurde die Entwicklung potenter und selektiver ABCG2 Inhibitoren immer wichtiger. Ziel dieser ...
Charakterisierung allosterischer Bindungsstellen von P2X4-Rezeptor-Modulatoren
(2017-04-24)
P2X-Rezeptoren stehen aufgrund ihrer Beteiligung an zahlreichen (patho)physiologischen Prozessen wie der Wahrnehmung von Schmerz, entzündlichen Veränderungen oder Krebs als Zielstrukturen für potentielle neue Wirkstoffe ...
Chromen-4-ones as novel potent and selective ligands for purinoceptor-related class A δ-branch orphan G protein-coupled receptors
(2017-05-15)
bout 100 of the roughly 800 members of the G protein-coupled receptor (GPCR) family are so-called orphan GPCRs whose endogenous ligand is not known or not confirmed yet. As the orphan receptors might qualify ...