E-Dissertationen: Suche
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Geostatistical Analysis of Genetic Diversity in the Present Male Argentine Population
(2015-08-03)
The geographical study of genetic diversity has a long history in fields related to population genetics. Its relevance has been already acknowledged in the 1940's and numerous tools have been developed since then. Most of ...
Statistical Analyses of Massive Stars and Stellar Populations
(2015-03-04)
Massive stars, i.e. stars more massive than about ten times that of the Sun, are key agents in the Universe. They synthesise many of the chemical elements that are so important for life on Earth, helped reionising the early ...
RNA aptamers as selective protein kinase inhibitors: New molecular tools for the elucidation of signal transduction pathways
(2015-04-16)
Elucidating the precise function of individual protein kinases within complex signal transduction cascades represents one of the greatest challenges in molecular biology. Protein kinases are enzymes that catalyze the ...
An Analysis and Evaluation of the Development of the QRD Human Product Information Template used in Package Leaflets
(2015-03-13)
Package leaflets of medicines distributed within the European Union must reflect the QRD template. Since the first edition of the QRD template from 1996, thirteen revisions have followed. During development the QRD template ...
Progressive orogenic deformation and metamorphism along the Combin Fault and Dent Blanche Basal Thrust in the Swiss-Italian Western Alps
(2015-03-24)
In the Western Alps of Switzerland and Italy, a stack of oceanic and continental units assembled during Late Cretaceous – Paleogene Alpine subduction, exhumation, and accretion. In the study area in the southern Valais and ...
Genetics of schizophrenia: Contribution of rare and low-frequency sequence variants in selected genomic regions to disease susceptibility
(2015-03-27)
Schizophrenia is a highly heritable, multifactorial mental disorder. Up to date, a number of common SNPs with low penetrance and large rare structural variants (CNVs) with higher penetrance have been identified to contribute ......
The ANOVA decomposition and generalized sparse grid methods for the high-dimensional backward Kolmogorov equation
(2015-03-12)
In this thesis, we discuss numerical methods for the solution of the high-dimensional backward Kolmogorov equation, which arises in the pricing of options on multi-dimensional jump-diffusion processes.
First, we apply ...
First, we apply ...
Biochemische, strukturelle und kinetische Charakterisierung des ungewöhnlichen c-Typ Cytochroms Thiosulfatdehydrogenase
(2015-02-24)
Thiosulfatdehydrogenasen sind Dihäm c-Typ Cytochrome mit einer ungewöhnlichen His/Cys-Koordination eines Hämes und weit verbreitet unter Bakterien. TsdA-Proteine kommen in allen Gruppen der Proteobakterien und auch in ......
Investigating the molecular mechanism of the anti-inflammatory effects of HDL in macrophages
(2015-03-17)
Inflammation is critical for clearing microbial infections, however, excessive or pro-longed inflammation is an underlying component of many disease states, including atherosclerosis. Macrophages recognise sterile or ......
Dating Early Archean partial melting events: insights from Re-Os dating of micrometric Os-minerals from Kalahari Craton mantle xenoliths
(2015-03-12)
Our understanding on the formation, mechanism and timing of the formation of the Earth’s earliest continents hinges on obtaining robust and accurate ages of melt depletion and lithosphere stabilisation. The Re-Os geochronometer ...