E-Dissertationen: Search
Now showing items 11-20 of 29
Synthesis of ganglioside and lysoganglioside lipoforms as internal standards for MS quantification
(2015-01-08)
The goal of this work was to establish methods for the synthesis of modified gangliosides that are suitable as internal standards for mass spectrometry. Quantification of gangliosides is usually achieved by staining after ...
New bioactive metabolites from the marine-derived fungus Dichotomomyces cejpii and their pharmacological relevance
(2015-01-13)
Natural products from fungal sources provide an astonishing diversity of bioactive molecules. The secondary metabolite production in fungi is strongly affected by environmental influences and the isolation of fungal strains ......
Investigation of two different aspects of stem cell biology: The role of Stat3 signaling and innate immunity in human pluripotent stem cells
(2015-01-08)
Human pluripotent stem cells (hPSCs) hold great promises as a model for development as well as a source for cells in regenerative medicine. Although hPSC research came into focus in the last decade, many aspects of the ...
Neuropeptides in stress reactivity: Role of enkephalin in response to chronic stress
(2015-01-29)
The incidence of mood pathologies, such as chronic anxiety and major depression, is a serious health problem in modern societies. The knowledge about the molecular mechanisms involved in the development of these disorders ...
Microglial sialic-acid-binding immunoglobulin-like lectin-H (Siglec-H) and Siglec-11 in neuroinflammation
(2015-01-16)
Sialic acid binding Siglecs are involved in various pathological processes. A minor fraction of Siglecs mediates activating signals via the ITAM linked DAP12 adaptor protein while the majority of Siglecs modulates inflammatory ......
Neuronal functions of RIM3γ and RIM4γ
(2015-09-25)
The large isoforms of the Rab3 interacting molecule (RIM) family, RIM1α/β and RIM2α/β are integral components of the cytomatrix of the presynaptic active zone. Through multiple interactions with other active zone proteins ...
Verwendung magnetischer Nanopartikel zur lentiviralen Transduktion und zielgerichteten Positionierung von Endothelzellen
(2015-07-14)
In den letzten Jahren hat die Forschung an Zellersatz- und Gentherapien stetig zugenommen, da diese bei Krankheiten, die bisher nicht oder nur unzureichend behandelt werden können, einen alternativen Ansatzpunkt bieten. ...
Study of the effect of mitochondrial deficiency on the neuronal morphology of the nematode Caenorhabditis elegans
(2015-07-07)
Neurons are highly polarized cells that constantly undergo remodeling of their branches during and after their development. This energy demanding process depends on energy provision from mitochondria via the oxidative ...
Die Rolle von Insertionselementen in der Evolution der Antibiotikaresistenz von Staphylococcus aureus
(2015-09-24)
Staphylococcus aureus nimmt beim Menschen eine ambivalente Rolle ein, da er einerseits als Kommensale die Haut und Schleimhäute der oberen Atemwege besiedelt und andererseits als pathogener Organismus eine Vielzahl ......
Alkyne lipid probes and azide detection reagents for in vitro enzymatic assays and highly sensitive lipid imaging
(2015-08-28)
Click chemistry has emerged as a powerful tool for the sensitive and specific labeling of biomolecules in various applications. For the design of lipid probes, a small and non-interfering tag is important to prevent ......
Alkinlipidsonden und Azidnachweisreagenzien für in vitro-Enzymassays und die hochempfindliche Mikroskopie von Lipiden
Die Click-Chemie hat sich zu einem wichtigen Werkzeug bei der sensitiven und ......
Alkinlipidsonden und Azidnachweisreagenzien für in vitro-Enzymassays und die hochempfindliche Mikroskopie von Lipiden
Die Click-Chemie hat sich zu einem wichtigen Werkzeug bei der sensitiven und ......