E-Dissertationen: Suche
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O-GlcNAc – a posttranslational modification implicated in Alzheimer disease?
(2015-04-22)
O-linked N-acetylglucosamine (O-GlcNAc) is a highly dynamic posttranslational modification which has been found on a myriad of nucleocytoplasmic proteins. O-GlcNAc addition and removal are catalyzed by two conserved enzymes, ......
Dnajc22 - a new susceptibility gene for salt-sensitive hypertension
(2015-06-10)
Chaperones of the heat shock (HSP) 70 family mediate elementary funtions in a cell, such as folding, oligomerization, transport, or degradation of proteins. Their function is particularly needed when cells are exposed to ...
Understanding social ecological change through palm use and management
(2015-03-31)
As people change their livelihood preferences, they change the way they relate to the natural resources around them. Anticipating and managing these changes, where possible, is a major challenge for sustainable land-use ......
Tetraspanin web formation and function
(2015-03-13)
The cell membrane is crucial for living cells; it encloses the intracellular matrix, maintains the concentration of cytosolic components, and controls the in-/outward signalling and interaction pathways. The cell membrane ...
The role of T helper 17 cells in the Pathogenesis of Human Onchocerciasis
(2015-03-31)
Onchocerciasis, also known as river blindness, is a tropical disease causing health and socioeconomic problems in endemic communities, especially sub-Saharan Africa. The disease is elicited by a filarial parasite called ......
Identification of Novel Causative Genes for Colorectal Adenomatous Polyposis
(2015-02-26)
In up to 50% of families with clinically verified adenomatous polyposis no germline mutations in the established genes APC and MUTYH can be identified during routine diagnostics although the presence of high numbers of ......
Novel insights into mechanisms and selectivity of the heterotrimeric G protein inhibitors BIM-46187 and FR900359
(2015-04-24)
Selective silencing of Gα protein subfamilies by small molecules is of great value to explore the contribution of G protein signaling in physiology and disease. It also represents a new opportunity to treat diseases, such ...
Carbon-carbon double-bond shift in the biosynthesis of the antibiotic corallopyronin A: CorJ DH*: a shift domain
(2015-03-13)
Corallopyronin A is a myxobacterial compound, which was isolated in our lab from the strain Corallococcus coralloides B035. It is a potent in vivo active antibiotic, which is currently undergoing preclinical studies. ...
Protein Function Prediction using Phylogenomics, Domain Architecture Analysis, Data Integration, and Lexical Scoring
(2015-03-18)
“As the number of sequenced genomes rapidly grows, the overwhelming majority of protein products can only be annotated computationally.” (Radivojac, Clark, Oron, et al. 2013) With this goal, three new protein function ...
The role of the cannabinoid receptor 2 in alcohol-induced neuroinflammation and alcohol addiction
(2015-02-11)
Chronic alcohol abuse leads to severe brain damage, which has been associated with alcohol-induced neuroinflammation. Recently, the cannabinoid receptor 2 (CB2), which is predominantly expressed on immune cells, ...