E-Dissertationen: Search
Now showing items 21-28 of 28
Design, Synthese und Biologische Testung neuartiger Chalkon-Derivate als ABCG2 Inhibitoren
(2017-04-24)
Multidrug Resistenz (MDR) von Krebszellen, verursacht durch eine gesteigerte Expression von ABC Transportern, zählt zu den Gründen für das Scheitern einer Chemotherapie. Die Entwicklung potenter und selektiver Inhibitoren ...
Investigations on the synthesis and reactivity of σ3λ3-oxaphosphirane complexes with fluorinated C-substituents
(2017-03-02)
The objective of this PhD work was to synthesize new oxaphosphirane complexes having the triphenylmethyl group bound to phosphorus. These derivatives may possess a higher lability of the P-C exocyclic bond than other ...
Localization of Paramagnetic Metal Ions in Biomolecules ny means of Electron Paramagnetic Resonance
(2017-03-23)
Localization of metal ion binding sites in biomolecules is an important objective in structural biology. Experimental methods that are commonly used to determine the location of metal ions, such as X-ray crystallography ...
Cellular biomechanics in 2D and 3D epithelial model tissues: from keratin intermediate filaments to breast gland in vitro reconstructed basement membranes
(2017-01-24)
The mechanical organization of biological tissue is crucial to the load-transmitting capacity of our bodies, and follows a hierarchical architecture that macroscopically results in organ’s formation and function. At the ......
Molecular Approach toward Gases Absorption by Ionic Liquids
(2017-01-24)
This thesis reports the theoretical studies of gas absorption in complex systems. These systems, namely ionic liquids, are considered to be promising candidates to substitute conventional gas capture systems which violate ...
Synthese, Modellierung und Evaluation supramolekularer 9,9’-Spirobifluoren-Rezeptoren zur Erkennung organischer Ammoniumionen
(2017-09-27)
Diese Dissertation befasst sich mit der experimentellen und quantenchemischen Untersuchung des Bindungsverhaltens supramolekularer 9,9’-Spirobifluoren-Rezeptoren gegenüber verschiedenen Aminosäureestern.
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Fusogene und endozytotische Liposomen: Vergleichende Untersuchungen zum Wirkstofftransport am Beispiel von Doxorubicin und Aclacinomycin A
(2017-09-21)
Liposomen sind zum Einschleusen von hydrophilen und hydrophoben Molekülen weit verbreitet. Über welchen Mechanismus die Liposomen in Zellen aufgenommen werden, ist entscheidend für die Wirksamkeit der transportierten ...
Investigations on 1,2-oxaphosphetane complexes
(2017-11-27)
In this thesis, first derivatives of previously unknown 1,2-oxaphosphetane complexes were synthesized, either by reaction of Li/Cl phosphinidenoid complexes with epoxides or by formal insertion into the OH bond of 2-iodoethanol ...