E-Dissertationen: Search
Now showing items 21-30 of 218
Particle engineered inhalable dry powders of rifampicin
(2019-12-12)
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Main site of infection are the lungs, but infection of other organs can occur in later stages. First line therapy includes antibiotic therapy ...
The impact and underlying molecular mechanisms of cell adhesion molecules integrins and syndecans in the cisplatin chemoresistance of melanoma cells
(2019-12-06)
Cancer is a complex, but also devastating disease, which today, more than ever, is present in our lives and society. Practically every person has a close relative or friend, or has been themselves affected by this disease. ...
Biochemical characterization, regulation, and inhibition of human transcription kinases CDK12 and CDK13 and human cell cycle-related kinase CDK14
(2019-11-27)
The transcription process is the first step in the molecular information flow from genome to proteome. In eukaryotes, the RNA polymerase II (RNAPII) transcribes genes that code for proteins by synthesizing pre-mature ...
Assay Development, Identification, Optimization and Pharmacological Characterization of Inhibitors for Ecto-5′-nucleotidase (CD73)
(2019-10-29)
Extracellular ATP acts as a proinflammatory signaling molecule via G protein-coupled P2Y receptors and ATP-gated P2X ion channel receptors. ATP is hydrolyzed by ecto-nucleotidases: In a first step ecto-nucleoside triphosphate ...
Synthese und Charakterisierung mehrkerniger metallosupramolekularer Aggregate auf der Basis des planar chiralen 4,15-disubstituierten [2.2]Paracyclophans
(2019-12-03)
Ziel dieses Promotionsprojektes war die Darstellung neuer metallosupramolekularer Aggregate aus planar chiralen, dissymmetrischen ditopen Liganden auf der Basis des 4,15-disubstituierten [2.2]Paracyclophans nach dem ...
Partitioning of carbon dioxide exchange in rapidly and slowly changing ecosystems
(2019-11-07)
Im Hinblick auf den aktuellen Klimawandel besteht die Frage, wie die Biosphäre auf den Globalen Wandel und die daraus hervorgehende lokale Landnutzungsänderung bezüglich ihres Kohlenstoffkreislaufes reagiert. Die Landoberfläche ...
Glass corrosion: Towards a Unifying Mechanistic Model
(2019-12-13)
Borosilicate glasses are currently used for the immobilization of highly radioactive waste and are materials of choice for many biomedical and research industries. They are metastable materials that corrode in aqueous ...
Optogenetics in striated muscle: defibrillation of the heart and direct stimulation of skeletal muscles with light
(2019-12-16)
Optogenetic depolarization of cells using the non-selective cation channel Channelrhodopsin-2 (ChR2) enables precise control over the membrane potential of cells within a specific area of intact organs. Furthermore, the ......
Semantic Segmentation and Completion of 2D and 3D Scenes
(2019-11-28)
Semantic segmentation is one of the fundamental problems in computer vision. This thesis addresses various tasks, all related to the fine-grained, i.e. pixel-wise or voxel-wise, semantic understanding of a scene. In the ...
New Results on the Probabilistic Analysis of Online Bin Packing and its Variants
(2019-12-03)
The classical bin packing problem can be stated as follows: We are given a multiset of items {a1, ..., an} with sizes in [0,1], and want to pack them into a minimum number of bins, each of which with ......