E-Dissertationen: Search
Now showing items 41-48 of 48
Molecular determinants of prostate cancer aggressiveness: an analysis of the interconnection between biomarkers,disease drivers and resistance mechanisms towardsnovel diagnostic, theranostic and therapeutic approaches
(2023-06-21)
The diagnosis of prostate cancer (PCa) is still mainly based on morphological criteria but is supported by biomarker analysis, which is currently mainly performed on an immunohistochemical basis. Newly developed techniques ......
Identification of cisplatin resistance mechanisms and alternative treatment options for testicular germ cell tumors
(2023-06-21)
Type II testicular germ cell tumors (TGCTs) are the most prevalent tumors in young men aged 18 to 35 years. TGCTs are classified as seminomas and non-seminomas. Embryonal carcinomas (EC), representing the cancer stem cell ...
Direkte pharmakologische Gq-Protein-Modulation in pulmonalen Gefäßen
(2023-04-04)
Heterotrimere G-Proteine können in vier Familien entsprechend ihrer alpha-Untereinheit unterteilt werden (Gs, Gi, G12/13 und Gq). Sie überführen ein extrazelluläres Signal nach der Aktivierung von G-Protein-gekoppelten ......
The Effects of Maternal Obesity on the Innate Immune System: Developmental Programming of Kupffer Cells
(2023-03-29)
The global epidemic of obesity has led to an increasing number of obese women in childbearing age. It is now understood that maternal obesity has harmful consequences on fetal and adult health. The underlying mechanism of ...
Deep Generative Modelling in Systems Medicine: From Transcriptomics Data to Drug Development
(2024-02-02)
(noch nicht zugänglich / not yet accessible)
Modulation der Expression und Funktion kardialer Gap Junction Kanäle
(2024-02-09)
Die elektrische Kopplung von Kardiomyozyten (KMs) im Herzen wird durch Connexine (Cx) vermittelt. Diese stellen durch die Bildung von Gap Junctions (GJs) Zell-Zell-Kontakte zwischen benachbarten KMs her. Im Herzmuskel ist ......
Analysis of the physiological response of perivascular adipose tissue during cold exposure
(2023-02-22)
Aortic valve disease (AVD) is common for people over 65 and its severity increases with age. Aortic aneurysm (AA) is the tenth cause of death for men above 55. Its prevalence was estimated to be up to 8.9% for men and up ...
Engagement of NKT cells during cross-priming enhances the CD8+ T cell response via GATA3 and IL-4/TNFα
(2022-04-21)
(noch nicht zugänglich / not yet accessible)