E-Dissertationen: Search
Now showing items 51-60 of 60
Analysis of the natural product biosynthesis in gliding bacteria using in vitro assays
(2017-01-10)
Natural products are most important in drug discovery and therapy, e.g. more than 80% of antibiotics are derived from microorganisms. Antimicrobial resistance is a global threat and thus an urgent need for new antimicrobial ...
The importance of endogenous cannabinoids in stress-related disorders and depression
(2017-02-03)
The endogenous cannabinoid system (ECS) is a unique neuromodulatory system, essentially involved in a variety of physiological processes. It consists of the two major endogenous cannabinoids (eCBs), anandamide and 2-AG, ......
Intra-mitochondriale Proteinaggregatablagerung als Schutzmechanismus der mitochondrialen Qualität
(2017-03-31)
Experimentelle Beobachtungen der letzten 10 Jahren zeigen zunehmende Evidenzen dafür, dass die aktive Zusammenlagerung von großen Proteinaggregaten einen höchst wirksamen Schutzmechanismus gegen proteotoxische Proteinsubtypen ...
Species Identification and Delimitation in Nemerteans
(2017-01-24)
The accurate identification and delimitation of species constitute the basis for assessing the biodiversity and phylogenetic relationships within the taxon Nemertea. However, working on nemertean taxonomy is challenging ...
Characterization of Staphylococcus aureus antigen-specific antibodies and application of their epitopes as active vaccine against MRSA
(2017-09-21)
Patients infected with the life-threatening, methicillin-resistant, human pathogen Staphylococcus aureus (MRSA) can be treated only with antibiotics of last resort. The development of a vaccine as an alternative to antibiotics ......
Evaluating the phylogenetic structure and microstructural evolution of organellar markers from both compartments in the reconstruction of a carboniferous radiation (mosses)
(2017-09-12)
In the reconstruction of the plant tree of life, sequence data from the plastid genome is currently favored as it contains a mixture of coding and noncoding regions, spanning different patterns of substitution rates and ...
Synthese, Modellierung und Evaluation supramolekularer 9,9’-Spirobifluoren-Rezeptoren zur Erkennung organischer Ammoniumionen
(2017-09-27)
Diese Dissertation befasst sich mit der experimentellen und quantenchemischen Untersuchung des Bindungsverhaltens supramolekularer 9,9’-Spirobifluoren-Rezeptoren gegenüber verschiedenen Aminosäureestern.
Dazu wurden ...
Dazu wurden ...
The immunomodulatory capacity of helminths on inflammation: Impact of eosinophils on E. coli-induced sepsis and genome-wide transcriptome profiling of human monocytes stimulated with helminth extract and LPS implicate immune functions and diseases
(2017-10-19)
Human filarial nematode infections cause lymphatic filariasis and onchocerciasis in more than 150 million people worldwide. An infection can result in debilitating clinical manifestations like visual impairment or lymphedema ......
Ein zellbasierter Biolumineszenzassay zur Untersuchung der Dimerisierung und Aggregation des Prionproteins
(2017-09-21)
Prionenerkrankungen wie z. B. die Creutzfeldt-Jakob-Krankheit bei Menschen oder die Bovine Spongiforme Encephalopathie (BSE) bei Rindern gehören zu den neurodegenerativen Erkrankungen. Grundlage aller Prionen-Krankheiten ...
Insights into the molecular adaptation of Staphylococcus aureus to copper Schiff´s base at proteome level
(2017-09-21)
The molecular adaptation of S.aureus to copper Schiff’s base (CSB) was studied by comparative proteome analysis. Proteome analysis was performed by employing nano LC-MALDI mass spectrometry with isobaric tags (iTRAQ) and ......