E-Dissertationen: Search
Now showing items 641-650 of 660
In vitro aqueous alteration experiments on cortical bone: Quantification and visualization of alteration effects from the micro- down to the atomic scale
(2022-10-14)
This dissertation addresses the effects of early diagenetic processes on vertebrate bone's organic and inorganic constituents in an aquatic environment.
For this purpose, in vitro alteration experiments were ...
For this purpose, in vitro alteration experiments were ...
From space to ground: spectroscopic and weak lensing analysis of galaxy observations and simulations
(2022-12-08)
Cosmology and astrophysics have entered an era of increasingly rich data sets, not only from ground- and space-based observations, but also from simulations. This has allowed us to advance in the most compelling science ...
Human iPSC-derived in vitro models of the peripheral nervous system for cellular pain and somatosensation research
(2022-01-07)
(noch nicht zugänglich / not yet accessible)
Charakterisierung der Neddylierung von Cofilin1: Einfluss auf die neuronale Entwicklung
(2022-12-22)
Nachdem lange davon ausgegangen wurde, dass die posttranslationale Modifikation durch Nedd8 nur bestimmte Culline und den Zellzyklus reguliert, sind in den vergangenen Jahren weitere neddylierte Proteine gefunden worden, ...
Fluorescent proteins for two-photon FLIM analysis of presynaptic protein interactions
(2020-06-10)
Monitoring Förster Resonance Energy Transfer (FRET) between fluorescent proteins (FPs) fused to proteins of interest is a powerful approach to study dynamic interactions of cellular proteins in living cells. The choice of ...
Supersaturation and solubilization to enhance the oral bioavailability of poorly soluble drug molecules: A mechanistic understanding of their potential and limitations
(2021-07-28)
The stabilization of the supersaturated state in solution was in the last few decades identified as a suitable strategy to enhance the oral bioavailability of poorly soluble drug molecules. From this point of view, drug ...
Function of Cytoplasmic FMR1-interacting protein 2 (CYFIP2) in spinal motor neuron morphology during mouse embryonic development
(2022-06-03)
The development of the nervous system is a tightly regulated spatio-temporal process that involves actin cytoskeletal dynamics. The remodelling of the neuronal cytoskeleton is important for dendritic and axonal guidance, ...
The Genomic Loci Cer-za and Cer-ye Contribute to Cuticular Wax Biosynthesis in Hordeum vulgare
(2022-06-28)
Changing environmental conditions demand the expansion of the genetic resources to enable the rapid adaption and development of novel crop species. The cuticle as direct interface between plants and their environment is ......
The chromatin organizer Satb1 regulates the differentiation into CD4+ TH subsets and is essential for the development of TH17 cells
(2021-06-04)
CD4+ T cells play a critical role in host defense and tissue homeostasis. Upon encountering their specific antigen, naive CD4+ T cells can differentiate into the effector T helper (TH) subsets ...
In vivo Relevant Drug Product Evaluation by Using the Biphasic Dissolution Assay (BiPHa+)
(2022-06-13)
An increasing number of new chemical entities struggled with a very poor solubility in aqueous media. Solubility or the ability to dissolve in intestinal media is obligatory for oral bioavailability. Dealing with this ......