E-Dissertationen: Search
Now showing items 61-68 of 68
The enzyme HPGD is critical for regulatory T cell function in adipose tissue
(2020-02-06)
Regulatory T cells (Treg cells) are essential for maintaining immune homeostasis. However, how Treg cells exert their function in tissue specific environments is often unknown. We have found ......
Locus coeruleus modulates locomotor activity via the medial septum and the diagonal band of Broca
(2020-10-02)
The locus coeruleus (LC) is positioned in the brainstem and one of the main sources of norepinephrine in the brain. With its projections throughout the whole brain, the LC plays an important role in regulating the general ...
Deciphering the role of the deubiquitinating enzyme Ataxin-3 in transcriptional regulation and the cellular response to stress
(2018-12-19)
Ataxin-3 (ATXN3), the disease-causing protein for Machado Joseph Disease (MJD) is functionally involved in the protein quality control and transcriptional regulation of various genes. Recent data suggest that either ...
Biophysical studies of EGFR conformation and interaction
(2019-03-26)
Epidermal growth factor receptor (EGFR) plays such a crucial role in cell signaling that its activity is intricately regulated. According to the prevailing activation model, EGF binding to EGFR initiates a series of ......
Direct lineage programming - a tool to generate and analyze human cortical layer specific neurons
(2020-05-14)
Until recently, lineage commitment and differentiation have been considered to be unidirectional and irreversible. This traditional view has dramatically changed with the advent of cellular reprogramming and direct cell ......
Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus
(2019-05-21)
Globally, at least 50 million people suffer from epilepsy and almost one third of these do not respond to treatment with one or even multiple antiepileptic drugs (AEDs). One of the most prominent approaches trying to explain ...
Click-SELEX enables the selection of Δ9-tetrahydrocannabinol-binding nucleic acids
(2019-05-10)
Δ9-Tetrahydrocannabinol (THC) is the main psychoactive compound in the plant Cannabis sativa and the most widely used illegal drug in the world. Its consumption impairs driving skills such as keeping a vehicle on track and ...
Reconciling Molecular with Biological and Morphological Data Towards an Integrative Analysis of the Evolutionary Biology of Chafers
(2018-03-20)
The research constituting this thesis acts at the interface of multiple disciplines related to biodiversity, combining data from morphology, genetics, geography, and ecology. Seven independent chapters (chapter II – chapter ...