E-Dissertationen: Search
Now showing items 1-10 of 652
Network effects of eslicarbazepine in the hippocampus
(2020-05-18)
Nearly 50 million people worldwide suffer from epilepsy, with 1/3 of the patients remaining without seizure control. This high number emphasizes the importance to develop new anti-epileptic drugs (AEDs) and to understand ...
Characterization of polygalacturonase inhibitor 1-like protein (CpPGIP) from Craterostigma plantagineum and analysis of stress inducible pcC13-62 promoters to understand desiccation tolerance in Linderniaceae
(2020-09-02)
The work is divided into two major parts. The first part is the characterization of an important cell wall protein “polygalacturonase inhibitor 1-like protein (CpPGIP)” and in the second part we studied “stress inducible ......
Comparative analysis of the insect mobile genetic element repertoire and its influence on genome size dynamics
(2020-06-10)
This thesis presents comparative genomics studies in insects as well as bioinformatics software development. Its empirical research part is focused mainly on mobile genetic elements, also termed transposable elements. The ......
Investigations on the early biosynthetic steps of griseorhodin A
(2012-05-03)
Presented here are the results concerning the early biosynthesis of the telomerase inhibitor griseorhodin A.
The griseorhodin biosynthetic gene cluster encodes components of a type II polyketide synthase (PKS). The ......
The griseorhodin biosynthetic gene cluster encodes components of a type II polyketide synthase (PKS). The ......
PPARγ in myeloid cells controls CNS autoimmunity
(2012-03-12)
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor that regulates the immunogenicity of myeloid cells such as dendritic cells (DCs), macrophages, and ......
Expressionssysteme zur Untersuchung der Pederin- und Psymberin-Biosynthese aus nicht kultivierten bakteriellen Symbionten
(2011-03-25)
Die vorliegende Arbeit beschäftigt sich mit der Expression und Charakterisierung von Enzymen der Pederin- und Psymberin-Biosynthese sowie mit den Fortschritten in der heterologen Expression des Pederin-Genclusters. Pederin ...
Contributions of keratins to epithelial cell architecture and signaling
(2011-07-04)
Keratin intermediate filament proteins form the major cytoskeleton in all epithelia. Increasing evidence suggests that keratins act as cytoskeletal scaffolds which locally regulate cell growth and survival. Many of these ...
Cytohesins are cytoplasmic ErbB receptor activators
(2011-07-12)
Signaling by ErbB receptors requires the activation of their cytoplasmic tyrosine kinase domains which is initiated by ligand binding to the receptor ectodomains. Up to now, cytoplasmic factors contributing to the activation ...
Validation of the novel label-free dynamic mass redistribution technology and its application for functional analysis of G protein-coupled receptors
(2011-07-04)
The dynamic mass redistribution (DMR) technology is a label-free assay platform that allows non-invasive and real-time recording of integrated cellular responses in living cells upon activation of G protein-coupled receptors ...
Analyse von Interaktionen des Hepatoma-derived growth factors (HDGF): Identifizierung und Charakterisierung eines HDGF enthaltenden Ribonukleo-Protein-Komplexes
(2012-03-20)
Der Hepatoma-derived growth factor (HDGF) wird in vielen Tumoren verstärkt exprimiert. Die Höhe der Expression korreliert dabei in einigen Tumorarten, wie z.B. dem hepatozellulären Karzinom, mit einer schlechten Prognose ...