E-Dissertationen: Search
Now showing items 1-10 of 42
Ai-based, behavior dependent approaches for connectomic reconstruction of neuronal circuits
(2022-03-24)
Characterizing the functional architecture of neuronal circuits that underly complex behavior requires identifying active neuronal ensembles during behavioral expressions of interest. The recent development of light-induced, ...
Selection of an aptamer and development of a genetic device to control mRNA stability in response to light
(2022-02-09)
Artificial autocatalytic RNA molecules, so-called aptazymes, are utilized as genetic devices to study and influence biological processes. These genetic devices consist of the autocatalytic RNA part, the ribozyme, and a ...
Perception and memories in the fly brain
(2022-02-03)
The brain is an extremely complex organ that controls thoughts, memories, motor skills and every process that is required to maintain our body alive and healthy. Although this is common knowledge, the mechanisms by which ...
Design, assembly, and operation of a self-regulating DNA rotaxane linear actuator
(2022-04-07)
DNA is not only the carrier of genetic information but also an excellent bottom-up material for constructing nanostructures due to its high degree of programmability. Interlocked DNA nanostructures have a potential use as ...
Gating of the Hv1 proton channel
(2022-03-28)
Hv1 is a voltage-gated proton channel, which is involved in the regulation of the intracellular pH (pHi) in immune cells. Among the voltage-gated ion channels, Hv1 is unique because it lacks a classical pore domain and its ...
Einblicke in die molekularen Mechanismen einer Tumorzell-induzierten Thrombozytenaktivierung und Identifikation von P-Selektin als essentiellen Rezeptor für die Aktivierung von Thrombozyten durch Mammakarzinomzelllinien
(2022-02-16)
Die Interaktion von Tumorzellen mit Thrombozyten trägt entscheidend zu einer erfolgreichen Metastasenbildung bei. Essentiell für die prometastatischen Effekte der Thrombozyten ist ihre Aktivierung durch Tumorzellen. Ziel ...
Biochemical and Structural Characterization of β-Hydroxylases in Non-Ribosomal Peptide Biosynthesis
(2022-02-02)
Hydroxylases are essential in the biosynthesis of natural products by functionalization of building blocks, which derive from primary metabolism. They provide hydrophily for specific interactions or enable further ...
Compartmentalisation of cAMP in Brown Adipocytes
(2022-02-14)
The second messenger, 3',5'-cyclic adenosine monophosphate (cAMP) plays an important role in governing the function and differentiation of brown adipocytes. Upon the stimulation of Gs-coupled G protein-coupled ...
Vorkommen Antibiotika-resistenter Bakterien in der aquatischen Umwelt: Zusammenhänge zu dem Vorkommen antibiotisch wirkender Substanzen
(2022-01-05)
Ein Anstieg der Resistenzen bei gleichzeitiger Stagnation hinsichtlich der Ent-wicklung neuer Antibiotika ist vor allem für Infektionen mit Gram-negativen Bakte-rien kritisch. Die WHO spezifizierte bereits 2014 ...
Design, synthesis and pharmacological evaluation of nucleotidic and non-nucleotidic inhibitors and probes for the ecto-5'-nucleotidase (CD73)
(2022-03-22)
Ecto-5'-nucleotidase (CD73) plays a central role in the metabolic breakdown of extracellular AMP. The enzyme is attached to the cell membrane by a glycosylphosphatidylinositol anchor, but can also be released by shedding, ...