E-Dissertationen: Search
Now showing items 1-10 of 14
Mining the Medical and Patent Literature to Support Healthcare and Pharmacovigilance
(2012-07-18)
Recent advancements in healthcare practices and the increasing use of information technology in the medical domain has lead to the rapid generation of free-text data in forms of scientific articles, e-health records, ...
INTERSNP: Genomweite Interaktionsanalyse mit a-priori Information
(2011-09-12)
Das Ziel der Genetischen Epidemiologie ist DNA Sequenzvarianten im menschlichen Genom zu finden, die an der Entstehung von Krankheiten beteiligt sind. Genomweite Assoziationsstudien haben zur Identifikation von hunderten ...
Information Extraction from Text for Improving Research on Small Molecules and Histone Modifications
(2011-07-18)
The cumulative number of publications, in particular in the life sciences, requires efficient methods for the automated extraction of information and semantic information retrieval. The recognition and identification of ...
Migration of interneuronal precursor cells in the developing cerebellum of mice: model-based cell tracking and simulation
(2010-12-10)
The navigation of precursor cells of inhibitory interneurons from their germinal zone inside the fourth ventricle through the white matter towards their final destination within the cerebellum's molecular layer is an ongoing ...
Microarrayanalyse gynäkologischer Tumorentitäten
(2013-07-10)
Softwareentwicklung Die Analyse von Genexpressionsprofilen fällt nicht länger exklusiv in den Aufgabenbereich von Bioinformatik Experten. Jedoch gestaltet sich der Erhalt von statistisch signifikanten Resultaten schwierig ......
Protein Function Prediction using Phylogenomics, Domain Architecture Analysis, Data Integration, and Lexical Scoring
(2015-03-18)
“As the number of sequenced genomes rapidly grows, the overwhelming majority of protein products can only be annotated computationally.” (Radivojac, Clark, Oron, et al. 2013) With this goal, three new protein function ...
Split Analysis Methods and Parametric Bootstrapping in Molecular Phylogenetics: Taking a closer look at model adequacy
(2015-06-08)
Even though the size of datasets in molecular analyses increased rapidly during the last years, undetected systematic errors as well as unsolved problems concerning the evaluation of data quality and adequate substitution ...
New bioactive metabolites from the marine-derived fungus Dichotomomyces cejpii and their pharmacological relevance
(2015-01-13)
Natural products from fungal sources provide an astonishing diversity of bioactive molecules. The secondary metabolite production in fungi is strongly affected by environmental influences and the isolation of fungal strains ......
Microglial sialic-acid-binding immunoglobulin-like lectin-H (Siglec-H) and Siglec-11 in neuroinflammation
(2015-01-16)
Sialic acid binding Siglecs are involved in various pathological processes. A minor fraction of Siglecs mediates activating signals via the ITAM linked DAP12 adaptor protein while the majority of Siglecs modulates inflammatory ......
Analysis of Biochemical Reaction Networks using Tropical and Polyhedral Geometry Methods
(2016-12-21)
The field of systems biology makes an attempt to realise various biological functions and processes as the emergent properties of the underlying biochemical network model. The area of computational systems biology deals ...