E-Dissertationen: Search
Now showing items 1-10 of 29
Consequence of FA2H Deficiency and FA2H Interaction Partners Revealed by Proteomic Analyses
(2015-03-10)
Fatty acid-2 hydroxylase (FA2H) is a 43 kDa transmembrane protein residing in the endoplasmic reticulum. As a monooxygenase it is responsible for the alpha–hydroxylation of fatty acids, which are later incorporated into ...
RNA aptamers as selective protein kinase inhibitors: New molecular tools for the elucidation of signal transduction pathways
(2015-04-16)
Elucidating the precise function of individual protein kinases within complex signal transduction cascades represents one of the greatest challenges in molecular biology. Protein kinases are enzymes that catalyze the ...
Genetics of schizophrenia: Contribution of rare and low-frequency sequence variants in selected genomic regions to disease susceptibility
(2015-03-27)
Schizophrenia is a highly heritable, multifactorial mental disorder. Up to date, a number of common SNPs with low penetrance and large rare structural variants (CNVs) with higher penetrance have been identified to contribute ......
Investigating the molecular mechanism of the anti-inflammatory effects of HDL in macrophages
(2015-03-17)
Inflammation is critical for clearing microbial infections, however, excessive or pro-longed inflammation is an underlying component of many disease states, including atherosclerosis. Macrophages recognise sterile or ......
Tetraspanin web formation and function
(2015-03-13)
The cell membrane is crucial for living cells; it encloses the intracellular matrix, maintains the concentration of cytosolic components, and controls the in-/outward signalling and interaction pathways. The cell membrane ...
The role of T helper 17 cells in the Pathogenesis of Human Onchocerciasis
(2015-03-31)
Onchocerciasis, also known as river blindness, is a tropical disease causing health and socioeconomic problems in endemic communities, especially sub-Saharan Africa. The disease is elicited by a filarial parasite called ......
A survey of the German mosquito fauna (Diptera: Culicidae) and identification of associated pathogens
(2015-02-13)
As a consequence of fundamental environmental, economic and demographic changes worldwide, vector-borne diseases are becoming of increasing public and animal health significance in Europe, owing to their geographical ...
Rheologie im Kopf
(2015-02-26)
In dieser Arbeit wird eine Methode präsentiert, welche die ortsaufgelöste Untersuchung viskoelastischer Eigenschaften von Hirngewebe ermöglicht.
Es werden drei Prototypen und deren elektropneumatische Ansteuerung ...
Es werden drei Prototypen und deren elektropneumatische Ansteuerung ...
Untersuchung des Einflusses des Endocannabinoidsystems auf das Schicksal, die Funktion und die Interaktion kardialer Zellen in vitro und in vivo
(2015-01-19)
Diverse Arbeiten demonstrieren den Einfluss des Endocannabinoidsystems (ECS) auf regulatorische Mechanismen im ischämischen Myokard. Besonders der Cannabinoidrezeptor 2 (CB2R) scheint an diesen Prozessen zu partizipieren ......
Molecular mechanisms underlying presynaptic plasticity: characterization of the RIM1α and SV2A interactome
(2015-02-11)
Synaptic plasticity encompasses various cellular mechanisms, which confer synapses the ability to react and adapt to ongoing changes in network activity. Some of the suggested mechanisms include remodelling and/or assembly ...