E-Dissertationen: Suche
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The role of Cysteine-rich with EGF-like domains 2 in the maintenance of metabolic homeostasis and regulation of the unfolded protein response
(2019-12-17)
Das Ziel dieser Arbeit war es, die Rolle von Creld2 bei der Aufrechterhaltung der metabolischen Homöostase unter Normalbedingungen und bei der Regulation der UPR unter ER Stressbedingungen zu untersuchen. Metabolische ...
Effects of intracranial stimulation and the involvement of the human parahippocampal cortex in perception
(2019-10-04)
How the human brain translates photons hitting the retina into conscious perception remains an open question. Throughout the medial temporal lobe (MTL), there are neurons (called concept cells) that change their firing ...
Pharmacometric approaches for linking pharmacokinetic and pharmacodynamic models of sunitinib and pazopanib with clinical outcome
(2019-07-22)
Aim of this thesis was to build a modeling framework for patients with metastatic renal cell carcinoma (mRCC) treated with two common first-line therapies, sunitinib and pazopanib. Therefore, as part of the European-wide ...
FR900359, an inhibitor of guanine nucleotide dissociation, effectively blunts signaling of GTPase-deficient Gq: mechanism of action and relevance for treating Gq-driven cancers
(2019-08-01)
Uveal melanoma (UM), the most common cancer of the adult eye, is known to have poor prognosis. Over 50% of patients are likely to develop metastasis. In more than 80% of the cases UM is driven by an activating mutation in ...
Impact of ERK signaling and its spatial regulation on cisplatin sensitivity in ovarian cancer cells
(2019-11-08)
The efficiency of the anticancer drug cisplatin in ovarian cancer is often limited by the development of cisplatin resistance. Cisplatin activates a plethora of DNA damage-related signaling pathways, which regulate the ...
Platelet-immune cell interactions in inflammation and cancer
(2019-09-10)
Platelets are well-known for their role in hemostasis and only more recently, they have also been acknowledged for their immune regulatory roles. Despite being small sized and anucleated, they can respond to inflammatory ...
Characterization of VKORC1L1 with respect to VKORC1
(2019-07-10)
Vitamin K reduction is essential and catalyzed by two enzymes in vitro. Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) reduces vitamin K to sustain γ-carboxylation of vitamin K dependent (VKD) proteins. This ...
Identification of novel TAM receptor interacting proteins: Screening for novel ligands
(2019-02-07)
The TAM receptors TYRO3, AXL, and MER are well characterized for their roles in cell proliferation and survival, phagocytosis, and inhibition of inflammation. The complexities of these TAM receptor responses imply a level ...
Protein and epigenetic biomarkers for variability in epidermal growth factor receptor inhibition in cancer treatment and characterization of the inhibitor-induced skin toxicity in an in vitro model
(2019-01-31)
Epidermal growth factor receptor (EGFR) is often over-expressed or over-activated in cells of solid tumors and can be targeted by specific inhibitors (EGFRIs), like erlotinib, gefitinib, cetuximab and panitumumab. ...
Formulierung von therapeutischen Oligonukleotiden mit PAMAM-Dendrimeren zur Aktivierung von Pattern Recognition Rezeptoren des angeborenen Immunsystems
(2019-05-03)
Der ubiquitär exprimierte Immunrezeptor Retinoic Acid inducible Gene-I, kurz RIG-I, ist eine zytosolisch lokalisierte Helikase, die zur Detektion von pathogenen RNA-Viren befähigt ist. Als synthetischer Ligand konnte eine ......