E-Dissertationen: Search
Now showing items 1-6 of 6
Benzimidazol-Analoga als Modulatoren von ABC-Transportern
(2011-10-17)
Humane ABC-Transporter (ATP-Binding-Casette) wie P-Glykoprotein (P-gp), die Multidrug Resistance associated Proteine (MRPs) oder Breast Cancer Resistance Protein (BCRP) stellen für die Arzneimitteltherapie einen sehr ...
Design und Synthese neuartiger Inhibitoren für den ABC-Transporter Breast Cancer Resistance Protein
(2011-05-31)
P-Glykoprotein (P-gp/ABCB1) und das Breast Cancer Resistance Protein (BCRP/ABCG2) sind humane ABC-Transporter mit einer multispezifischen Substraterkennung. Sie werden verstärkt an physiologischen Barrieren exprimiert und ...
Systematic Identification of Scaffolds Representing Different Types of Structure-Activity Relationships
(2011-07-22)
In medicinal chemistry, it is of central importance to understand structure-activity relationships (SARs) of small bioactive compounds. Typically, SARs are analyzed on a case-by-case basis for sets of compounds active ...
Ambigols A-C and tjipanazole D: bioinformatic analysis of their putative biosynthetic gene clusters
(2011-08-04)
Cyanobacteria are Gram negative, photoautotrophic bacteria, which are distinguished by an impressive array of chemically diverse natural products. The here investigated cyanobacterial strain of Fischerella ambigua was shown ...
Novel Secondary Metabolites from Endophytic Marine-derived Fungi
(2011-02-22)
The marine environment is distinguished by unique groups of organisms being the source of a wide array of fascinating structures. Marine microorganisms, such as fungi often occur associated with macroorganisms like algae, ...
The Human Adenosine A2B Receptor: Homology Modeling, Virtual Screening, and Computer-aided Drug Design
(2011-02-10)
The adenosine A2B receptor belongs to the class A of G protein-coupled receptors. It is playing a crucial role in cell signalling and various physiological responses. The adenosine A2B receptor, a ...