E-Dissertationen: E-Dissertationen: Recent submissions
Now showing items 101-120 of 4370
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Exploring and Addressing General Limitations of Compound Potency Predictions using Machine Learning
(2025-03-24)Compound potency prediction is a major task in computational drug discovery. Regression models based on machine learning (ML) approaches have become popular for small molecule potency predictions. Recently, deep learning ... -
Synthesis of Chromophore Decorated Ligands and their Self-Assembly into Supramolecular Coordination Complexes
(2025-03-20)This thesis is concerned with the synthesis and characterization of chromophore decorated self-assembled coordination complexes (SCC’s). The SCC’s were constructed from ditopic bispyridine ligands as organic donor building ... -
Establishment of bioanalytical workflows for the quality assessment of formulated proteins
(2025-03-17)Proteins and peptides contribute to a significant class of therapeutic agents in the pharmaceutical market. Over the last decades, they gained growing interest due to their safety and specificity compared to small molecule ... -
Rab requirements in HOPS-mediated late endosome-lysosome tethering and dissection of fusion factor requirements in Ca2+-dependent phagosome-lysosome fusion
(2025-03-17)Through sequential fusion with early- and late endosomes (EEs and LEs) and ultimately lysosomes (LYS), a degradative (endo-)lysosome ((E)LYS is formed. Directionality of fusion is ensured by the action of Ras-like GTPases ... -
Transcriptomic heterogeneity of microglia in relation to Alzheimer's disease-associated pathology and post-mortem delay
(2025-03-17)(noch nicht zugänglich / not yet accessible) -
Advanced deep learning methods for quantifying imaging biomarkers in large cohort studies
(2025-03-14)Understanding the anatomical structures of the body and brain, and their influence on human health throughout the lifespan is of significant research and clinical interest. Tracking of structural changes can provide insights ... -
Multi-Person Pose Tracking in Videos
(2025-03-14)This thesis addresses the complex challenges of multi-person pose estimation and tracking in dynamic, real-world environments. Motivated by advancements in artificial intelligence and the growing need for natural human-machine ... -
Investigating the molecular mechanisms involved in the developmental assembly of the mushroom body calyx in Drosophila melanogaster
(2025-03-11)How a circuit functions can be investigated by examining the organisation of the circuit to be able to decipher the connectivity logic and the logic of information flow within that circuit. Hence, to understand how the ... -
Transverse Momentum Dependent Parton Distribution Functions from Twisted Mass Lattice QCD
(2025-03-09)The aim of this thesis is the theoretical calculation of the unpolarized transverse momentum dependent parton distribution function (TMDPDF) from first principles using lattice QCD. TMDPDFs are important quantities that ... -
Addressing Domain Shift in CNN-based Image Segmentation: From Improving Robustness to Unsupervised and Active Learning based Domain Adaptation
(2025-03-07)Pixel-wise labeling of images is a common task in applications nowadays as it allows humans and machines to make sense of the content in an image and informs their decisions about subsequent steps to be taken. Examples of ... -
Environmentally induced development of pulmonary monocyte-derived alveolar macrophages is controlled by Apolipoprotein E and Dectin-1
(2025-03-06)The lung is one of the largest barrier tissues of our body, and is constantly exposed to the environment. By inhaling, the lungs do not only take up oxygen, which is crucial for cellular respiration, but also a plethora ... -
Investigating Graphene-Based Systems: Interaction Effects, Localization, and Finite-Temperature Dynamics
(2025-03-05)This dissertation presents a comprehensive theoretical and numerical investigation into the electronic properties of graphene‐based systems, with a focus on interaction effects, localization phenomena, and finite‐temperature ... -
Ultracold fermions in periodically-driven superlattices
(2025-03-05)This thesis presents quantum simulation of strongly-correlated systems beyond standard Hubbard models, using ultracold fermionic potassium atoms in both static and periodically-driven optical superlattices. For this study, ... -
Adaptive Geospatial Data Representation for Data Analytics and Sharing in the Mobility Domain
(2025-02-25)In recent years, the mobility domain has gained attention from urban planners and researchers due to its essential role in enhancing urban safety and development. This interest can be attributed to the increased availability ... -
Quantum optimal transport for AF-C*-algebras
(2025-02-14)We introduce quantum optimal transport of states on tracial AF-C*-algebras to study non-spatial transport of quantum information, and view it as the pointwise case of a general parametrised one. We define quantum optimal ... -
A Cell Panel to Characterise Tau Aggregation
(2025-02-13)(noch nicht zugänglich / not yet accessible) -
Betrachtung des Zellmetabolismus mit Fokus auf Hexokinase 2 und IGFBP-2 im Tumorresistenzgeschehen
(2025-02-11)Bei der Behandlung solider Tumore mit Zytostatika ist oft eine Resistenzentwicklung zu verzeichnen, die ein Therapieversagen verursachen kann. Es ist bekannt, dass Tumorzellen oft einen veränderten Stoffwechsel besitzen. ... -
Analysis of the cAMP-regulated metabolome of skeletal muscle and adipose tissue
(2025-02-10)(noch nicht zugänglich / not yet accessible) -
The essential role of Cytohesin-2 as a regulator of intracellular transport
(2025-02-06)The protein family of cytohesins, comprising cytohesin-1 to -4, was identified between 1996 and 2000 as small guanine nucleotide exchange factors for ADP ribosylation factor (ARF) GTPases. Since then, the function of ... -
Boundary conditions and dynamics of fluvial obstacle mark formation
(2025-02-05)Obstacles like boulders, riparian vegetation, and man-made structures such as bridge piers are common in fluvial environments. When exposed to flow, they form characteristic geomorphological and sedimentary structures known ...
