E-Dissertationen: Browsing E-Dissertationen by Classification (DDC) "ddc:570"
Now showing items 1-20 of 169
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Across Diagnostic Boundaries: Genetic Variants for Neuropsychiatric Disorders and their Association with Human Brain Structure
(2025-08-11)With the advances in genome-wide association studies (GWAS), hundreds of genetic variants have been identified for neuropsychiatric disorders. Strikingly, many of these genetic variants showed complex associations across ... -
ADAR1 deficiency in regulatory T cells leads to MDA5 and PKR dependent systemic autoimmunity in mice
(2026-04-02)Type I interferon (IFN-I) production, triggered by innate sensors upon recognition of viral nucleic acids, is essential for antiviral host defense. Mutations in proteins involved in nucleic acid metabolism, sensing and ... -
Advanced polygenic prediction models via statistical boosting
(2025-03-06)In times of growing availability of large biobanks with extensive genetic data, polygenic prediction modeling has gained importance and aims at capturing an individual's genetic predisposition to specific, often complex, ... -
Advances in Machine Learning Approaches for Biostatistical Learning
(2025-06-27)This habilitation thesis summarized current state-of-art advances in machine learning for biomedical applications. The first contribution was the development of a framework for tuning KDSN to increase prediction performance ... -
AIM2-Inhibitory Nanobodies Reveal Differential Activation of AIM2 and NLRP3 Inflammasomes by Poxvirus DNA Genomes in Primary Human Cells
(2025-08-05)Poxviruses are large double-stranded (ds)DNA viruses that replicate in the cytoplasm. While variola virus (VARV) caused millions of deaths before its eradication in 1980, monkeypox virus (MPXV) has been declared a public ... -
Aktivierung des angeborenen Immunsystems im Zentralnervensystem nach subchronischer Alkoholbehandlung im Mausmodell
(2020-06-03)Alkohol ist als kulturell anerkanntes Rauschmittel in seinen ökonomischen, sozialen und gesundheitlichen Risiken weiterhin unterschätzt. In der Literatur zeigen sich Hinweise auf die Relevanz unterschiedlicher Trinkmuster ... -
Analyse von Sialinsäuren in der humanen Retina: Ein Pilotversuch mit Etablierung eines Verfahrens zur Detektion von Polysialinsäuren
(2025-09-30)Polysialinsäuren sind polymere Kohlenhydratverbindungen, die im zentralen Nervensystem nicht nur an Entwicklungs- und Regenerationsprozessen beteiligt sind, sondern auch eine Rolle in der Regulation zellulärer und humoraler ... -
Angiostatische Gentherapie mittels adenoviral vermittelter löslicher VEGF-Rezeptor-Komplexe im murinen Metastasenmodell des kolorektalen Karzinoms
(2007)EINLEITUNG: Das kolorektale Karzinom (CRC) stellt in der westlichen Welt sowohl bei Männern als auch bei Frauen die zweithäufigste Tumorentität dar. Die Bildung metastatischer Absiedelungen unter anderem in der Leber ... -
Antagonistic Nanobodies Reveal Mechanism of Gasdermin D Pore Formation and Unexpected Therapeutic Potential
(2025-04-01)Activation of various inflammasomes converges on the cleavage of gasdermin D (GSDMD) by pro-inflammatory caspases, followed by oligomerization of the N-terminal domain (GSDMD<sup>NT</sup>) and the assembly of pores penetrating ... -
Antiviral and antimicrobial inflammasome formation in intestinal epithelial cells
(2024-08-13)Inflammasomes coordinate inflammation by inducing rapid cytokine secretion and protect against invading pathogens by initiating death of infected cells. We developed and characterised a novel fluorescent reporter that ... -
Astrocyte morphology determines properties of the astroglial networks
(2021-09-29)Astrocytes are very abundant glial cells in the brain. They perform many functions: provision of nutrient to the neurons, maintenance of extracellular ion balance, shaping of network operations and synaptic signaling and ... -
A basal forebrain to midbrain circuit drives exploratory locomotion
(2023-10-26)Locomotion is a fundamental behavior that comprises different specialized neuronal networks. In the basal forebrain, the glutamatergic neurons of the medial septum and diagonal band of Broca (MSDB<sub>glu</sub>) can initiate ... -
Bilateral inflammation after unilateral UVR-B irradiation: Ocular cross-talk and immunomodulation between exposed and unexposed, contralateral eye
(2021-01-29)The presented study investigates the influence of exposure of one eye to UVR-B on the unexposed, partner eye in vivo in a mouse model. Furthermore, we try to answer the question whether this sympathizing reaction of the ... -
CA1 Network Dynamics During Impaired Working Memory in Temporal Lobe Epileptic Mice
(2023-06-12)Around 50 million people worldwide suffer from epilepsy. Seizures are not the only feature of epilepsy that patients suffer from. Despite the fact that other comorbidities of epilepsy such as memory deficits widely impact ... -
The cell biology of the FcRn-albumin recycling system
(2022-08-10)Human serum albumin (HSA) is the most abundant protein in plasma and has an exceptionally long circulatory half-life of around three weeks in humans. The enhanced half-life properties of HSA result from the selective ... -
Cellular and molecular defence mechanisms against Legionella infection
(2024-01-26)The two most prevalent causes of Legionnaires’ disease are <em>L. pneumophila</em> and <em>L. longbeachae</em>. The rising incidence of the Legionnaires’ disease over the past two decades together with the increasing ... -
Cellular and molecular dynamics of splenic myeloid cells during blood-stage malaria
(2024-10-29)The spleen is a secondary lymphoid organ with the essential function of maintaining blood homeostasis through its function as a filtering system. Aberrant erythrocytes and infectious particles are recognized and eliminated ... -
Characterisation of Extracellular Vesicles Released upon NLRP3 Activation and Their Impact on Bystander Cells
(2020-02-17)Inflammasomes are cytosolic multi-protein complexes that assemble upon detection of danger signals of infectious or sterile origin. Activation of the NOD-like receptor NLRP3 results in activation of caspase-1, which ... -
Characterisation of Inflammasome-Induced Extracellular Vesicles, Their Uptake by and Effect on Bystander Cells
(2023-12-22)Inflammasomes are multimeric complexes whose activation triggers caspase 1 cleavage resulting in processing of the cytokines interleukin (IL) 1β and IL-18, and the pore-forming protein gasdermin D. This, in turn, initiates ... -
Characterization of a novel multiprotein complex downstream of the cytosolic nucleic acid sensors cGAS and RIG-I
(2021-08-30)Detection of viral nucleic acids by specialized PRRs of the innate immune system triggers the expression of type I IFNs, a hallmark of antiviral defense. In vertebrates, the cGAS-STING pathway and the RLR-MAVS pathway have ...
