E-Dissertationen: Auflistung E-Dissertationen nach Klassifikation (DDC) "ddc:570"
Anzeige der Dokumente 1-20 von 133
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A basal forebrain to midbrain circuit drives exploratory locomotion
(2023-10-26)Locomotion is a fundamental behavior that comprises different specialized neuronal networks. In the basal forebrain, the glutamatergic neurons of the medial septum and diagonal band of Broca (MSDB<sub>glu</sub>) can initiate ... -
Advanced polygenic prediction models via statistical boosting
(2025-03-06)In times of growing availability of large biobanks with extensive genetic data, polygenic prediction modeling has gained importance and aims at capturing an individual's genetic predisposition to specific, often complex, ... -
Aktivierung des angeborenen Immunsystems im Zentralnervensystem nach subchronischer Alkoholbehandlung im Mausmodell
(2020-06-03)Alkohol ist als kulturell anerkanntes Rauschmittel in seinen ökonomischen, sozialen und gesundheitlichen Risiken weiterhin unterschätzt. In der Literatur zeigen sich Hinweise auf die Relevanz unterschiedlicher Trinkmuster ... -
Angiostatische Gentherapie mittels adenoviral vermittelter löslicher VEGF-Rezeptor-Komplexe im murinen Metastasenmodell des kolorektalen Karzinoms
(2007)EINLEITUNG: Das kolorektale Karzinom (CRC) stellt in der westlichen Welt sowohl bei Männern als auch bei Frauen die zweithäufigste Tumorentität dar. Die Bildung metastatischer Absiedelungen unter anderem in der Leber ... -
Antagonistic Nanobodies Reveal Mechanism of Gasdermin D Pore Formation and Unexpected Therapeutic Potential
(2025-04-01)Activation of various inflammasomes converges on the cleavage of gasdermin D (GSDMD) by pro-inflammatory caspases, followed by oligomerization of the N-terminal domain (GSDMD<sup>NT</sup>) and the assembly of pores penetrating ... -
Antiviral and antimicrobial inflammasome formation in intestinal epithelial cells
(2024-08-13)Inflammasomes coordinate inflammation by inducing rapid cytokine secretion and protect against invading pathogens by initiating death of infected cells. We developed and characterised a novel fluorescent reporter that ... -
Astrocyte morphology determines properties of the astroglial networks
(2021-09-29)Astrocytes are very abundant glial cells in the brain. They perform many functions: provision of nutrient to the neurons, maintenance of extracellular ion balance, shaping of network operations and synaptic signaling and ... -
Bilateral inflammation after unilateral UVR-B irradiation: Ocular cross-talk and immunomodulation between exposed and unexposed, contralateral eye
(2021-01-29)The presented study investigates the influence of exposure of one eye to UVR-B on the unexposed, partner eye in vivo in a mouse model. Furthermore, we try to answer the question whether this sympathizing reaction of the ... -
CA1 Network Dynamics During Impaired Working Memory in Temporal Lobe Epileptic Mice
(2023-06-12)Around 50 million people worldwide suffer from epilepsy. Seizures are not the only feature of epilepsy that patients suffer from. Despite the fact that other comorbidities of epilepsy such as memory deficits widely impact ... -
The cell biology of the FcRn-albumin recycling system
(2022-08-10)Human serum albumin (HSA) is the most abundant protein in plasma and has an exceptionally long circulatory half-life of around three weeks in humans. The enhanced half-life properties of HSA result from the selective ... -
Cellular and molecular defence mechanisms against Legionella infection
(2024-01-26)The two most prevalent causes of Legionnaires’ disease are <em>L. pneumophila</em> and <em>L. longbeachae</em>. The rising incidence of the Legionnaires’ disease over the past two decades together with the increasing ... -
Cellular and molecular dynamics of splenic myeloid cells during blood-stage malaria
(2024-10-29)The spleen is a secondary lymphoid organ with the essential function of maintaining blood homeostasis through its function as a filtering system. Aberrant erythrocytes and infectious particles are recognized and eliminated ... -
Characterisation of Extracellular Vesicles Released upon NLRP3 Activation and Their Impact on Bystander Cells
(2020-02-17)Inflammasomes are cytosolic multi-protein complexes that assemble upon detection of danger signals of infectious or sterile origin. Activation of the NOD-like receptor NLRP3 results in activation of caspase-1, which ... -
Characterisation of Inflammasome-Induced Extracellular Vesicles, Their Uptake by and Effect on Bystander Cells
(2023-12-22)Inflammasomes are multimeric complexes whose activation triggers caspase 1 cleavage resulting in processing of the cytokines interleukin (IL) 1β and IL-18, and the pore-forming protein gasdermin D. This, in turn, initiates ... -
Characterization of a novel multiprotein complex downstream of the cytosolic nucleic acid sensors cGAS and RIG-I
(2021-08-30)Detection of viral nucleic acids by specialized PRRs of the innate immune system triggers the expression of type I IFNs, a hallmark of antiviral defense. In vertebrates, the cGAS-STING pathway and the RLR-MAVS pathway have ... -
Characterization of the pro-inflammatory activity of short-chain fatty acids (SCFAs)
(2021-10-13)Short-chain fatty acids (SCFAs), which are mainly derived from microbial fermentation of dietary fibres, have been considered to be beneficial to gut health for decades. Recently, a few of studies reported that some patients ... -
Characterization of the zinc-sensitive metal-regulatory transcription factor 1 in hippocampal epileptic network formation using an animal model of Temporal Lobe Epilepsy
(2023-10-02)Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. It usually occurs after a transient brain insult, including status epilepticus (SE), which triggers a latent period of epileptogenesis prior to the ... -
Characterizing a novel hepatic NK-like T cell population and defining its function during antiviral immune response
(2025-03-24)The family of NK-like (NK1.1+) T cells is extremely heterogeneous, with the most predominant members being the type-I and type-II NKT cells. In addition to that, other unconventional T cells, like gamma-delta T and MAIT ... -
Chronic Helminth Infection Ameliorates Colitis via ***** regeneration program
(2022-03-07)(noch nicht zugänglich / not yet accessible) -
Combining genetic and single-cell expression data to expand the understanding of orofacial clefting
(2025-03-26)Molecular malfunctions during craniofacial development can lead to non-syndromic cleft lip with or without cleft palate (nsCL/P), a congenital malformation that affects the upper lip and palate. Treatment involves ...
