eDissertationen: Browsing eDissertationen by Classification (DDC) "ddc:570"
Now showing items 1-20 of 22
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Aktivierung des angeborenen Immunsystems im Zentralnervensystem nach subchronischer Alkoholbehandlung im Mausmodell
(2020-06-03)Alkohol ist als kulturell anerkanntes Rauschmittel in seinen ökonomischen, sozialen und gesundheitlichen Risiken weiterhin unterschätzt. In der Literatur zeigen sich Hinweise auf die Relevanz unterschiedlicher Trinkmuster ... -
Angiostatische Gentherapie mittels adenoviral vermittelter löslicher VEGF-Rezeptor-Komplexe im murinen Metastasenmodell des kolorektalen Karzinoms
(2007)EINLEITUNG: Das kolorektale Karzinom (CRC) stellt in der westlichen Welt sowohl bei Männern als auch bei Frauen die zweithäufigste Tumorentität dar. Die Bildung metastatischer Absiedelungen unter anderem in der Leber ... -
Characterisation of Extracellular Vesicles Released upon NLRP3 Activation and Their Impact on Bystander Cells
(2020-02-17)Inflammasomes are cytosolic multi-protein complexes that assemble upon detection of danger signals of infectious or sterile origin. Activation of the NOD-like receptor NLRP3 results in activation of caspase-1, which ... -
Essential and complementary function of dendritic cell subsets during immunotherapy
(2020-03-11)T lymphocytes are critical components of the adaptive immune system that protects us against a variety of infections. However, during chronic infections such as with HIV, HCV and HBV as well as cancers, T cells become ... -
Establishment of an inducible human pluripotent stem cell-based 3D model of Alzheimer's disease
(2020-11-16)Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the aged population. The vast majority of cases are sporadic, however, various mutations may cause early-onset, familial AD (FAD) variants. AD is ... -
Evaluation der MDA-5 abhängigen Immunstimulation durch virale Replikons und enzymatisch hergestellte Polynukleotide
(2013-07-19)Bei einer Infektion des Körpers durch ein Pathogen muss das Immunsystem schnell reagieren, um eine Ausbreitung des Krankheitserregers zu verhindern. Dies geschieht durch hochkonservierte Strukturen (pathogen associated ... -
Function and diversity of myeloid cells during chronic inflammation in non-lymphoid organs
(2020-03-10)Different immune cells play a major role in maintaining tissue homeostasis, tissue repair but also in inflammation. Tissue integrity is mainly controlled by tissue regulatory T cells (Tregs), type 2 innate ... -
Functional and cellular heterogeneity of the myeloid cell system
(2020-11-09)Cells of the myeloid lineage form the innate part of the immune system and are characterized by a high level of functional plasticity, which is required to address the diverse set of functions of these mononuclear cells. ... -
Funktionelle und molekulare Charakterisierung von Kaliumkanälen in hippocampalen Astrozyten
(2017-08-04)Für die Funktion von Astrozyten in der zerebralen Ionen-, Transmitter- und Metabolitenregulation sowie Kontrolle des zerebralen Blutflusses ist ihre hohe Kaliumleitfähigkeit essentiell. Unter pathophysiologischen Bedingungen ... -
Immune defense mechanisms against Legionella longbeachae
(2020-01-30)The pulmonary epithelial barrier is the first line of defense against pathogens invading the lungs. If those are able to overcome this first barrier, myeloid cells of the innate immune system are instrumental for the ... -
Impact of chronic liver inflammation on adaptive immune responses to viral infection
(2020-03-11)A common complication in patients suffering from chronic liver inflammation and fibrosis is the enhanced susceptibility to viral infections and weak responses to vaccination, which are associated with significant co-morbidities. ... -
Investigating the molecular basis of human NLRP1 inflammasome activation
(2020-03-10)Cytosolic sensor proteins like NLRP1 (NOD-like receptor containing a pyrin domain 1) play a fundamental role in mediating innate immunity. Upon activation they form signalling hubs that recruit the adaptor protein ASC ... -
MAIT cell diversity, function and impact on dendritic cells
(2020-04-01)T cells represent an important component of the immune system. Whilst early studies were largely focused on the role of conventional CD8+ and CD4+ T cells that recognize peptide-antigens in association ... -
Neuroinflammation, microglia and the cell biology of Alzheimer's Disease
(2020-04-08)The pathology of Alzheimer’s disease (AD) is characterised by progressive accumulation of misfolded proteins, which form senile plaques and neurofibrillary tangles, and chronic inflammation in the brain associated with ... -
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations: The establishment of translating ribosome affinity purification
(2020-11-04)Recoding of in-frame UGA/Seccodon in selenoproteins requires a complex translational machinery. The core of this event is the interaction between selenocysteine insertion sequence (SECIS element) in the 3’UTR of ... -
Structural and functional principles of long-range connectivity in the rat vibrissal system
(2020-11-05)Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian neocortex. Integrating feedforward thalamo-cortical (TC) and recurrent intracortical (IC) inputs with those from top down cortical-cortical ... -
Structure and function study of HCN1 channel by forming a lattice on the membrane
(2020-09-08)Hyperpolarized-activated cyclic nucleotide-gated (HCN) channels play complex and diverse roles in the regulation of neuronal and network excitability. Aberrant expression, trafficking, and post-translational modifications ... -
Synaptische Innervation als Richtungsgeber für migrierende Vorläufer zentralnervöser Interneurone
(2016-11-30)Interneuron-Vorläuferzellen migrieren während der Entwicklung weite Strecken von den Orten, an denen sie generiert werden, zu ihren Bestimmungsorten, an denen sie sich differenzieren und synaptisch in neuronale Netzwerke ... -
Toll-like Rezeptor 8 stimuliert die Funktion neutrophiler Granulozyten
(2010-07-08)Granulozyten stellen die größte Leukozytenpopulation im peripheren Blut dar. Sie sind zirkulierenden Toll-like-Rezeptor - Liganden direkt ausgesetzt.
In der vorliegenden Arbeit wurde erstmals untersucht, ob und wie ... -
Unravelling the role of RIM proteins in synaptic transmission: RIM1α tunes Ca2+ channel subtype contribution to neurotransmitter release
(2019-04-12)Synaptic transmission is extremely fast and tightly regulated due to the rapid and spatially restricted Ca2+ signal at the presynaptic active zone (AZ). At the AZ, voltage-gated Ca2+ channels (VGCC) ...
