E-Dissertationen: Auflistung E-Dissertationen nach Klassifikation (DDC) "ddc:570"
Anzeige der Dokumente 21-40 von 97
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Establishment of an inducible human pluripotent stem cell-based 3D model of Alzheimer's disease
Hebisch, Matthias Alexander Sebastian (2020-11-16)Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the aged population. The vast majority of cases are sporadic, however, various mutations may cause early-onset, familial AD (FAD) variants. AD is ... -
Evaluation der MDA-5 abhängigen Immunstimulation durch virale Replikons und enzymatisch hergestellte Polynukleotide
Henn, Alina (2013-07-19)Bei einer Infektion des Körpers durch ein Pathogen muss das Immunsystem schnell reagieren, um eine Ausbreitung des Krankheitserregers zu verhindern. Dies geschieht durch hochkonservierte Strukturen (pathogen associated ... -
Extracellular Vesicles in Hepatobiliary Cancer Management
Urban, Sabine Katharina (2023-04-19)Cancer is a global health problem that will intensify in the upcoming years and decades. Hepatobiliary cancers, comprising hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA) and gallbladder carcinoma (GbCA), are among ... -
Fatty liver disrupts homeostatic functions of Kupffer cells in liver regeneration
Panetas, Ioannis (2022-04-22)Obesity-associated liver disease represents a continuously increasing health concern. Besides the risk of obese individuals towards liver dysfunction, cirrhosis and hepatocellular carcinoma, an increased risk for defective ... -
From pattern recognition to pro-inflammatory cell death - Functional characterization of the proteins NLRP7 and GSDMD
Kopp, Anja (2023-12-07)Inflammasomes are cytosolic multi-protein complexes that form in response to infection or other harmful stimuli to induce innate immune responses. The core components of inflammasomes are pattern recognition ... -
Function and diversity of myeloid cells during chronic inflammation in non-lymphoid organs
Liene, Sebastian (2020-03-10)Different immune cells play a major role in maintaining tissue homeostasis, tissue repair but also in inflammation. Tissue integrity is mainly controlled by tissue regulatory T cells (T<sub>regs</sub>), type 2 innate ... -
Functional and cellular heterogeneity of the myeloid cell system
Günther, Patrick (2020-11-09)Cells of the myeloid lineage form the innate part of the immune system and are characterized by a high level of functional plasticity, which is required to address the diverse set of functions of these mononuclear cells. ... -
Functions of the DEAH-box helicase DHX36 in type I interferon signaling
Hilbig, Daniel (2023-01-06)The induction of type I interferons (IFN) is a hallmark of foreign nucleic acids immune sensing by the innate immune system. Based on the universal molecular structure of DNA and RNA throughout all kingdoms of life, the ... -
Funktionelle und molekulare Charakterisierung von Kaliumkanälen in hippocampalen Astrozyten
Weller, Johannes Michael (2017-08-04)Für die Funktion von Astrozyten in der zerebralen Ionen-, Transmitter- und Metabolitenregulation sowie Kontrolle des zerebralen Blutflusses ist ihre hohe Kaliumleitfähigkeit essentiell. Unter pathophysiologischen Bedingungen ... -
FVIII-albumin fusion proteins enhance the induction of immune tolerance towards coagulation factor VIII in haemophilia A mice
Maione, Andrea (2024-09-19)Haemophilia A (HemA) is an X-linked recessive disease caused by the lack of functional coagulation factor VIII (FVIII) causing life-threatening prolonged bleeding events due to a coagulation incapacity. HemA is treated by ... -
Genetic analyses on male-pattern hair loss: Exploring links with rare variants, COVID-19 and short anagen hair syndrome
Henne, Sabrina Katrin (2024-09-10)Male pattern hair loss (MPHL) is a highly heritable condition and the most common form of hair loss in men. The phenotype is characterized by progressive hair loss in the frontotemporal and vertex areas of the scalp. ... -
Global 3’-UTR Length Changes Form a Novel Layer of Regulation in the Macrophage Response to Interferon-Beta
Straub, Sarah (2022-05-20)Interferon signaling is one of the most important mechanisms shaping innate immune responses and needs to be tightly regulated to successfully fight infections and modulate immune responses while avoiding toxicity. <br ... -
Heterogeneity in Kupffer cell-mediated killing of Staphylococcus aureus
Chetrusca Covash, Andrian (2024-07-24)<em>Staphylococcus aureus</em>, an opportunistic pathogen, exhibits remarkable adeptness in evading the host's innate immune defenses to establish infections. In this context, Kupffer cells, specialized resident macrophages ... -
Immune activation by DNA sensors in ANCA associated vasculitis
Krollmann, Calvin (2024-03-04)Anti-neutrophilic cytoplasmatic antibody (ANCA) associated vasculitis (AAV) is a group of rare inflammatory autoimmune diseases primarily affecting the small vessels of kidney and lung. Current treatment options mainly ... -
Immune defense mechanisms against Legionella longbeachae
Scheiding, Victoria Madeleine (2020-01-30)The pulmonary epithelial barrier is the first line of defense against pathogens invading the lungs. If those are able to overcome this first barrier, myeloid cells of the innate immune system are instrumental for the ... -
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
Friker, Lea Lydia Magdalena (2021-10-26)Die Alzheimer-Krankheit stellt die weltweit häufigste Form der Demenz dar. Die genauen Mechanismen, welche zu ihrer Entstehung führen, sind bis heute nicht vollständig verstanden. Eine wichtige Rolle spielt die Aktivierung ... -
Impact of aging and enriched environment on α-synuclein propagation
Kraus, Tanja (2022-04-06)Parkinson's disease (PD) is the second most common neurodegenerative disease. The prevalence of sporadic PD results from a complex interaction of demographic, genetic, and environmental factors. Age is one of the strongest ... -
Impact of chronic liver inflammation on adaptive immune responses to viral infection
Assmus, Lisa Mareike (2020-03-11)A common complication in patients suffering from chronic liver inflammation and fibrosis is the enhanced susceptibility to viral infections and weak responses to vaccination, which are associated with significant co-morbidities. ... -
Influence of antiviral RNA binding effector proteins on innate immune responses
Ciupka, Katrin (2024-08-06)The efficient elimination of viruses is initiated by the recognition of the viral nucleic acid genome or replication intermediates through innate immune receptors. Several different receptors specifically detect double ... -
Influence of the Fatty Acid Saturation Levels on Inflammatory Signalling in Melanoma Cells
Liebing, Jana (2023-09-11)Due to their rapid proliferation, tumour cells have an enhanced demand for lipids. Therefore, increased lipogenesis is considered as a hallmark of cancer. In melanoma, the lineage addiction oncogene MITF regulates the ...