E-Dissertationen: Auflistung E-Dissertationen nach Klassifikation (DDC) "ddc:615"
Anzeige der Dokumente 1-20 von 24
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Activation of the innate immune system by endoplasmic reticulum stress and proteasome inhibition
(2023-08-24)The impact of proteotoxic stress on innate immune activation is currently unclear. Here, I investigated differential effects of ER stress and proteasome inhibition using genetically modified cell lines and primary human ... -
Biologika in der Therapie der juvenilen idiopathischen Arthritis: Eine Risikoanalyse
(2022-01-24)<strong> Einleitung</strong> Der Einsatz von Biologika zur Behandlung der juvenilen idiopathischen Arthritis geht mit spezifischen Risiken im Hinblick auf potentielle Nebenwirkungen einher. Ziel dieser Arbeit war es, die ... -
Blutungsbedingte Nebenwirkungen der Therapie des Blepharospasmus und Hemispasmus facialis mit Botulinumneurotoxin unter antithrombotischer Medikation
(2024-03-04)Ziel der Studie war es die Häufigkeit und Tragweite blutungsbedingter Nebenwirkungen der Behandlung des benignen essentiellen Blepharospasmus (BEB) und Hemispasmus facilais (HFS) mit Botulinumneurotoxin A (BoNT/A) unter ... -
Chronic Helminth Infection Ameliorates Colitis via ***** regeneration program
(2022-03-07)(noch nicht zugänglich / not yet accessible) -
Contribution of SIGLEC-11 and SIGLEC-16 receptors to neuro-inflammation and neurodegeneration
(2023-02-14)Brain aging is a multifactorial process including accumulation of aged lipids and proteins, neuroinflammation and loss of neurons. SIGLEC-11 and SIGLEC-16 are paired opposite inhibitory- versus activatory-signaling ... -
Control of pulmonary immunity by physical exercise
(2024-03-06)Sedentary lifestyles combined with high caloric nutrition are widely known to severely contribute to the rise of metabolic diseases like diabetes, atherosclerosis, or obesity in recent years. While endurance training has ... -
Determining the epigenetic synergy of a repurposed drug and identification of prognosis-related lncRNAs in liver cancer and hematologic malignancies
(2023-11-02)<strong>Background:</strong> Epigenetics is crucial in cancer research, revealing its impact on diverse cancer types' development and progression. Epigenetic-targeting drugs show promise in improving patient outcomes, but ... -
Einfluss der Cyclin-abhängigen Kinase 5 auf die Expression des Programmed Cell Death Ligand 1 in murinen Pankreaskarzinomen im Vergleich verschiedener Analysemethoden
(2023-03-23)<strong>Einleitung:</strong> Programmed Cell Death Ligand 1 (PD-L1) ist ein immuninhibitorisches Molekül, das für gewöhnlich von bestimmten Immunzellen oder dendritischen Zellen exprimiert wird. Auch verschiedene Tumoren ... -
Inducing immunity to liver stage malaria through endogenous tissue resident memory cells
(2020-12-16)Tissue-resident memory CD8 T (TRM) cells provide effective tissue surveillance and can respond rapidly to infection due to their strategic location. Within the liver, TRM cells can induce effective protection against ... -
Inflammation-dependent differentiation of two distinct regulatory T cell populations in the visceral adipose tissue shapes systemic metabolism
(2023-12-07)Visceral adipose tissue (VAT) is an endocrine organ critical for energy storage and metabolic homeostasis. It harbours a plethora of immune cells, which play an important role in maintaining tissue homeostasis. A large ... -
Influence of antiviral RNA binding effector proteins on innate immune responses
(2024-08-06)The efficient elimination of viruses is initiated by the recognition of the viral nucleic acid genome or replication intermediates through innate immune receptors. Several different receptors specifically detect double ... -
Lipid droplet formation drives pathogenic ILC2 responses in airway inflammation
(2020-06-08)The Western world is affected by a dramatic increase of chronic inflammatory diseases like asthma, Crohn’s disease and psoriasis. Innate lymphoid cells (ILC) play an important role in the control and maintenance of barrier ... -
Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice
(2021-07-13)Parkinson’s disease is one of the most common neurodegenerative diseases in the elderly population, with a pathophysiology linked to neuroinflammation, complement activation and oxidative damage. Soluble polysialic acid ... -
Modulation der antibakteriellen Immunantwort in Blut und Aszites durch von Immunzellen produzierten Katecholamine bei Patienten mit Leberzirrhose
(2024-01-05)<strong>Hintergrund und Ziele:</strong> Der Verlauf einer Leberzirrhose mit Aszites kann durch verschiedenste Parameter beeinflusst werden. Im Rahmen der vorliegenden Arbeit wurde untersucht, ob Immunzellen im Blut und / ... -
Nanoparticle delivery of molecular agents to tackle HIV latency
(2022-09-16)Antiretroviral therapy (ART) effectively suppresses HIV replication in people living with HIV (PLWH), but treatment is lifelong. The persistence of long-lived, latently infected resting CD4<sup>+</sup>T cells is a significant ... -
Nucleic acid sensing in CD4 T cells during HIV-1 and other viral infections
(2021-10-15)Viruses are small intracellular parasites and use the host cell’s biosynthesis machinery to replicate and spread. Therefore, viral particles incorporate structures that are similar to the ones that naturally occur within ... -
Nucleic acid sensing in CD8 T cells and NK cells during viral infections
(2024-09-09)Pathogens can be detected by a variety of germline encoded pattern recognition receptors (PRR) that recognize highly conserved pathogen-associated molecular patterns (PAMPs). Among these receptors, Retinoic Acid-Inducible ... -
Opioide im Vergleich: Effektivität und Sicherheit von Oxycodon und Piritramid zur Analgesie bei Mittelohreingriffen
(2021-10-18)<strong>Hintergrund:</strong> Eine rein intravenöse Opioidtherapie ist mit zusätzlichem Material-, Organisations-, Personal- und Ressourcenaufwand sowie einem erhöhtem Risiko an Nebenwirkungen und potenziell notwendigen ... -
RIG-I agonists as effective anti-viral prophylaxis and treatment in a mouse model of severe SARS-CoV-2 infection
(2022-07-08)The recent outbreak of the COVID-19 pandemic highlights the need for novel prophylactic and therapeutic countermeasures against newly emerging viruses. Innate immune receptor agonists are considered to be a promising new ... -
RIG-I-like receptors in aortic inflammation and calcification
(2025-02-26)It has been already well established that erroneous detection of endogenous nucleic acids by the innate immune system drives pathogenic processes of autoimmunity. Along with that, gain-of function mutations in the RIG-I-like ...
