E-Dissertationen: Browsing E-Dissertationen by Classification (DDC) "ddc:615"
Now showing items 1-20 of 32
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Activation of the innate immune system by endoplasmic reticulum stress and proteasome inhibition
(2023-08-24)The impact of proteotoxic stress on innate immune activation is currently unclear. Here, I investigated differential effects of ER stress and proteasome inhibition using genetically modified cell lines and primary human ... -
Arcyriaflavin A as a Potential Therapeutic Agent for Osteoporosis
(2025-09-29)In this study, Arcyriaflavin A (ArcyA), a natural compound derived from the marine organism Eudistoma sp., was investigated as a potential therapeutic approach for osteoporosis. To evaluate the inhibitory effects of ArcyA ... -
Biologika in der Therapie der juvenilen idiopathischen Arthritis: Eine Risikoanalyse
(2022-01-24)<strong> Einleitung</strong> Der Einsatz von Biologika zur Behandlung der juvenilen idiopathischen Arthritis geht mit spezifischen Risiken im Hinblick auf potentielle Nebenwirkungen einher. Ziel dieser Arbeit war es, die ... -
Blutungsbedingte Nebenwirkungen der Therapie des Blepharospasmus und Hemispasmus facialis mit Botulinumneurotoxin unter antithrombotischer Medikation
(2024-03-04)Ziel der Studie war es die Häufigkeit und Tragweite blutungsbedingter Nebenwirkungen der Behandlung des benignen essentiellen Blepharospasmus (BEB) und Hemispasmus facilais (HFS) mit Botulinumneurotoxin A (BoNT/A) unter ... -
Chronic Helminth Infection Ameliorates Colitis via ***** regeneration program
(2022-03-07)(noch nicht zugänglich / not yet accessible) -
Contribution of SIGLEC-11 and SIGLEC-16 receptors to neuro-inflammation and neurodegeneration
(2023-02-14)Brain aging is a multifactorial process including accumulation of aged lipids and proteins, neuroinflammation and loss of neurons. SIGLEC-11 and SIGLEC-16 are paired opposite inhibitory- versus activatory-signaling ... -
Control of pulmonary immunity by physical exercise
(2024-03-06)Sedentary lifestyles combined with high caloric nutrition are widely known to severely contribute to the rise of metabolic diseases like diabetes, atherosclerosis, or obesity in recent years. While endurance training has ... -
Determining the epigenetic synergy of a repurposed drug and identification of prognosis-related lncRNAs in liver cancer and hematologic malignancies
(2023-11-02)<strong>Background:</strong> Epigenetics is crucial in cancer research, revealing its impact on diverse cancer types' development and progression. Epigenetic-targeting drugs show promise in improving patient outcomes, but ... -
Die Rolle von Fraktalkin in der Aristolochiasäure-induzierten Nephropathie
(2024-08-12)Die Fraktalkin (CX3CL1/R1) Achse spielt eine bedeutende Rolle in der Rekrutierung von Immunzellen in verschiedenste Organe. In dieser Arbeit untersuchten wir die Rolle von CX3CR1 exprimierenden Immunzellen in der ... -
Einfluss der Cyclin-abhängigen Kinase 5 auf die Expression des Programmed Cell Death Ligand 1 in murinen Pankreaskarzinomen im Vergleich verschiedener Analysemethoden
(2023-03-23)<strong>Einleitung:</strong> Programmed Cell Death Ligand 1 (PD-L1) ist ein immuninhibitorisches Molekül, das für gewöhnlich von bestimmten Immunzellen oder dendritischen Zellen exprimiert wird. Auch verschiedene Tumoren ... -
Einfluss von hypoxisch-ischämischem Hirnschaden auf die Neurogenese und das strukturelle sowie funktionelle Outcome im Rattenmodell
(2025-08-15)<strong>Hintergrund und Zielsetzung:</strong><br/> Die hypoxisch-ischämische Enzephalopathie (HIE) bei Neugeborenen entsteht durch eine mangelhafte Versorgung des Gehirns mit Sauerstoff und Nährstoffen rund um die Geburt. ... -
Inducing immunity to liver stage malaria through endogenous tissue resident memory cells
(2020-12-16)Tissue-resident memory CD8 T (TRM) cells provide effective tissue surveillance and can respond rapidly to infection due to their strategic location. Within the liver, TRM cells can induce effective protection against ... -
Inflammation-dependent differentiation of two distinct regulatory T cell populations in the visceral adipose tissue shapes systemic metabolism
(2023-12-07)Visceral adipose tissue (VAT) is an endocrine organ critical for energy storage and metabolic homeostasis. It harbours a plethora of immune cells, which play an important role in maintaining tissue homeostasis. A large ... -
Influence of antiviral RNA binding effector proteins on innate immune responses
(2024-08-06)The efficient elimination of viruses is initiated by the recognition of the viral nucleic acid genome or replication intermediates through innate immune receptors. Several different receptors specifically detect double ... -
Investigating potential therapeutic targets, biomarkers, and preclinical models in malignant solid tumors
(2026-04-02)As malignant diseases remain to be associated with high morbidity and mortality, the search for more effective therapeutics and biomarkers is a critical medical need. Research efforts in the last decade have led to the ... -
Lipid droplet formation drives pathogenic ILC2 responses in airway inflammation
(2020-06-08)The Western world is affected by a dramatic increase of chronic inflammatory diseases like asthma, Crohn’s disease and psoriasis. Innate lymphoid cells (ILC) play an important role in the control and maintenance of barrier ... -
Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice
(2021-07-13)Parkinson’s disease is one of the most common neurodegenerative diseases in the elderly population, with a pathophysiology linked to neuroinflammation, complement activation and oxidative damage. Soluble polysialic acid ... -
Modulation der antibakteriellen Immunantwort in Blut und Aszites durch von Immunzellen produzierten Katecholamine bei Patienten mit Leberzirrhose
(2024-01-05)<strong>Hintergrund und Ziele:</strong> Der Verlauf einer Leberzirrhose mit Aszites kann durch verschiedenste Parameter beeinflusst werden. Im Rahmen der vorliegenden Arbeit wurde untersucht, ob Immunzellen im Blut und / ... -
Molecular pathomechanisms of immune-mediated epileptogenesis
(2025-12-03)This thesis explores the immune-mediated and molecular mechanisms underlying AE and epileptogenesis, with a particular emphasis on T cell-dependent neuroinflammation and the transcriptional dynamics across different stages ... -
Molekular-pharmakologische Ansätze zur Sensitivierung von Glioblastom-Zellen gegenüber Temozolomid
(2026-07-16)Glioblastome gehören zu den aggressivsten Tumoren des Gehirns und zeichnen sich durch infiltratives Wachstum, Nekrose und mikrovaskuläre Proliferation aus. Seit nunmehr 20 Jahren besteht die Therapie aus Operation, ...
