E-Dissertationen: Search
Now showing items 21-30 of 44
The role of innate lymphoid cells in liver disease: Identification of a hepatic IL-13-producing ILC3-like population potentially involved in liver fibrosis
(2022-05-23)
Innate lymphoid cells (ILCs) are a family of innate immune cells that mirror the functionality of T lymphocytes but do not express rearranged antigen receptors. As tissue-resident cells, ILCs primarily reside in peripheral ...
Role of IFN‑γ induced genes in cell autonomous defence against Legionellae
(2022-05-27)
L. pneumophila and L. longbeachae are ubiquitous environmental bacteria that can cause a severe pneumonia, known as Legionnaires’ Disease, when contaminated aerosols are inhaled by susceptible humans. During ......
Interplay of IKKs and IKK-related kinases in antiviral nucleic acid receptor signaling in human monocytes
(2022-06-21)
Monocytes and monocyte-derived cells are among the first line of host defense against
invading pathogens. They are equipped with pattern recognition receptors (PRRs) that
detect conserved components of microbes and in ...
Participation of Ste20-like kinase-deficient neurons in the abnormal circuitry of focal epileptogenic lesions
(2022-01-03)
Focal epileptogenic lesions displaying morphologically altered neurons are frequently associated with devastating and therapy-refractory epilepsies. However, it is still unsolved how dysplastic neurons contribute to the ...
Characterization of a novel multiprotein complex downstream of the cytosolic nucleic acid sensors cGAS and RIG-I
(2021-08-30)
Detection of viral nucleic acids by specialized PRRs of the innate immune system triggers the expression of type I IFNs, a hallmark of antiviral defense. In vertebrates, the cGAS-STING pathway and the RLR-MAVS pathway have ......
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
(2021-10-26)
Die Alzheimer-Krankheit stellt die weltweit häufigste Form der Demenz dar. Die genauen Mechanismen, welche zu ihrer Entstehung führen, sind bis heute nicht vollständig verstanden. Eine wichtige Rolle spielt die Aktivierung ......
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
Alzheimer’s Disease is the world’s most common cause of dementia. The exact mechanisms causing neurodegeneration ......
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
Alzheimer’s Disease is the world’s most common cause of dementia. The exact mechanisms causing neurodegeneration ......
MAIT cell diversity, function and impact on dendritic cells
(2020-04-01)
T cells represent an important component of the immune system. Whilst early studies were largely focused on the role of conventional CD8+ and CD4+ T cells that recognize peptide-antigens in association ...
The cell biology of the FcRn-albumin recycling system
(2022-08-10)
Human serum albumin (HSA) is the most abundant protein in plasma and has an exceptionally long circulatory half-life of around three weeks in humans. The enhanced half-life properties of HSA result from the selective ...
Pathogenetic insights from novel mouse models for human epilepsy-associated developmental glioneuronal tumors
(2022-09-21)
Background: Developmental, biologically benign brain tumors associated with epilepsy represent a highly heterogeneous group of neoplasms and include glioneuronal and glial entities. Gangliogliomas (GGs) ......
Presenilin deficiency leads to altered protein N-glycosylation and endo-lysosomal cholesterol accumulation
(2022-11-08)
Major genetic causes of familial Alzheimer disease are mutations in genes encoding presenilin (PS) 1 and 2. PS1 and PS2 are known to constitute the catalytic subunits of the γ-secretase complex, but also for being ......