E-Dissertationen: Suche
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Modelling melanoma control by immunotherapy and tissue-resident memory T cells using CRISPR/Cas9-based approaches
(2020-02-03)
In recent years, immunotherapy has demonstrated remarkable efficacy in the treatment of metastatic melanoma due to the development of T cell-based therapies such as checkpoint inhibitors or adoptive T cell transfer therapy ......
Characterisation of Extracellular Vesicles Released upon NLRP3 Activation and Their Impact on Bystander Cells
(2020-02-17)
Inflammasomes are cytosolic multi-protein complexes that assemble upon detection of danger signals of infectious or sterile origin. Activation of the NOD-like receptor NLRP3 results in activation of caspase-1, which ...
Investigating the molecular basis of human NLRP1 inflammasome activation
(2020-03-10)
Cytosolic sensor proteins like NLRP1 (NOD-like receptor containing a pyrin domain 1) play a fundamental role in mediating innate immunity. Upon activation they form signalling hubs that recruit the adaptor protein ASC ...
The role of T cell help in shaping Dendritic Cell function
(2020-02-07)
CD8+ T cell priming depends on antigen presentation by dendritic cells (DCs) and their capacity to communicate contextual cues associated with antigen acquisition. DCs often also require additional signals from ......
The role of cytohesins in the regulation of immune responses
(2020-02-17)
Cytohesins are guanine nucleotide exchange factors for adenosine diphosphate ribosylation factor (Arf) proteins and promote the switch of Arfs to the active GTP-bound form. Cytohesins have been shown in different in vitro ......
Impact of chronic liver inflammation on adaptive immune responses to viral infection
(2020-03-11)
A common complication in patients suffering from chronic liver inflammation and fibrosis is the enhanced susceptibility to viral infections and weak responses to vaccination, which are associated with significant co-morbidities. ...
Neuroinflammation, microglia and the cell biology of Alzheimer's Disease
(2020-04-08)
The pathology of Alzheimer’s disease (AD) is characterised by progressive accumulation of misfolded proteins, which form senile plaques and neurofibrillary tangles, and chronic inflammation in the brain associated with ...
Immune defense mechanisms against Legionella longbeachae
(2020-01-30)
The pulmonary epithelial barrier is the first line of defense against pathogens invading the lungs. If those are able to overcome this first barrier, myeloid cells of the innate immune system are instrumental for the ......
Machbarkeitsstudie zur praktischen Anwendung von Evidenzbasierter Medizin im Rahmen des humanmedizinischen Studiums im Fachbereich für Allgemeinmedizin
(2020-05-05)
Einleitung: Zukünftige Ärzte sollen in Evidenzbasierter Medizin (EbM) unterrichtet werden. Bisher wurde dieses Thema an medizinischen Ausbildungsstätten ausschließlich auf theoretischer Basis vermittelt.
Ziel ...
Stellenwert der Muttermilch-assoziierten CMV-Infektion bei sehr unreifen Frühgeborenen
(2021-03-04)
Diese Dissertation beschäftigt sich speziell mit der Fragestellung, wie groß der Stellenwert der CMV-Übertragung über Muttermilch bei sehr unreifen Frühgeborenen (<28 SSW) ist.
In der vorliegenden Studie wurden ...
In der vorliegenden Studie wurden ...