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Now showing items 11-20 of 96
Synaptische Innervation als Richtungsgeber für migrierende Vorläufer zentralnervöser Interneurone
(2016-11-30)
Interneuron-Vorläuferzellen migrieren während der Entwicklung weite Strecken von den Orten, an denen sie generiert werden, zu ihren Bestimmungsorten, an denen sie sich differenzieren und synaptisch in neuronale Netzwerke ...
Aktivierung des angeborenen Immunsystems im Zentralnervensystem nach subchronischer Alkoholbehandlung im Mausmodell
(2020-06-03)
Alkohol ist als kulturell anerkanntes Rauschmittel in seinen ökonomischen, sozialen und gesundheitlichen Risiken weiterhin unterschätzt. In der Literatur zeigen sich Hinweise auf die Relevanz unterschiedlicher Trinkmuster ...
Bilateral inflammation after unilateral UVR-B irradiation: Ocular cross-talk and immunomodulation between exposed and unexposed, contralateral eye
(2021-01-29)
The presented study investigates the influence of exposure of one eye to UVR-B on the unexposed, partner eye in vivo in a mouse model. Furthermore, we try to answer the question whether this sympathizing reaction of the ...
The role of sympathetic neurons in modulating resident muscularis macrophage functions during postoperative ileus and mucosal antimicrobial responses in homeostasis: Sympathetic neurons in intestinal homeostasis and disease
(2022-02-09)
Introduction: The sympathetic nervous system (SNS) innervates large parts of the gastrointestinal tract. Its projections are densely found in tunica muscularis externa and reach up to the mucosa, the ...
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations: The establishment of translating ribosome affinity purification
(2020-11-04)
Recoding of in-frame UGA/Seccodon in selenoproteins requires a complex translational machinery. The core of this event is the interaction between selenocysteine insertion sequence (SECIS element) in the 3’UTR of ...
Structural and functional principles of long-range connectivity in the rat vibrissal system
(2020-11-05)
Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian neocortex. Integrating feedforward thalamo-cortical (TC) and recurrent intracortical (IC) inputs with those from top down cortical-cortical ...
Search for exosomes in NG2-glial cells
(2022-02-17)
NG2-glial cells is an abundant and widely distributed subtype of glia, featuring properties not typically associated with mature glial cells, such as the ability to receive synaptic input from neurons, or adult proliferation. ...
Establishment of an inducible human pluripotent stem cell-based 3D model of Alzheimer's disease
(2020-11-16)
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the aged population. The vast majority of cases are sporadic, however, various mutations may cause early-onset, familial AD (FAD) variants. AD is ...
Funktionelle und molekulare Charakterisierung von Kaliumkanälen in hippocampalen Astrozyten
(2017-08-04)
Für die Funktion von Astrozyten in der zerebralen Ionen-, Transmitter- und Metabolitenregulation sowie Kontrolle des zerebralen Blutflusses ist ihre hohe Kaliumleitfähigkeit essentiell. Unter pathophysiologischen Bedingungen ...
Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice
(2021-07-13)
Parkinson’s disease is one of the most common neurodegenerative diseases in the elderly population, with a pathophysiology linked to neuroinflammation, complement activation and oxidative damage. Soluble polysialic acid ...