E-Dissertationen: Search
Now showing items 31-40 of 65
The mind's ratio: How the balance between ω-6 and ω-3 fatty acids affects the risk of late-life dementia
(2022-02-03)
Dementia health care costs are rapidly rising due to the increasing number of people with dementia worldwide that is expected to increase to 66 million by 2030 and 115 million by 2050 (Prince et al., 2013). Intensive ......
Unravelling the role of RIM proteins in synaptic transmission: RIM1α tunes Ca2+ channel subtype contribution to neurotransmitter release
(2019-04-12)
Synaptic transmission is extremely fast and tightly regulated due to the rapid and spatially restricted Ca2+ signal at the presynaptic active zone (AZ). At the AZ, voltage-gated Ca2+ channels (VGCC) ...
RIG-I agonists as effective anti-viral prophylaxis and treatment in a mouse model of severe SARS-CoV-2 infection
(2022-07-08)
The recent outbreak of the COVID-19 pandemic highlights the need for novel prophylactic and therapeutic countermeasures against newly emerging viruses. Innate immune receptor agonists are considered to be a promising new ...
Targeting the Microbiome by NLRP6 Deletion and the Development of Murine Alzheimer’s Disease
(2022-07-11)
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain
disorder. The progression of AD is characterized by the deposition of amyloid-β
peptides and hyperphosphorylated Tau proteins, causing loss ...
Investigation of Heat Shock Protein 70 and Toll-like Receptor 4 functions during inflammation reaction by mechanical compression in human periodontal ligament cells
(2021-06-24)
Biomechanical forces exerted during treatment with orthodontic appliances cause tensile and compressive strain within the periodontal ligament (PDL) of affected teeth followed by ischemia on the compression side. Further, ...
Somatic cell-derived extracellular vesicles and phenotypic outcomes in the next generation
(2023-05-31)
Evidence from both human and animal studies demonstrate that paternal experiences and exposures can cause phenotypic changes in the next generation. Extracellular vesicles (EVs) released by somatic cells are hypothesised ...
Extracellular Vesicles in Hepatobiliary Cancer Management
(2023-04-19)
Cancer is a global health problem that will intensify in the upcoming years and decades. Hepatobiliary cancers, comprising hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA) and gallbladder carcinoma (GbCA), are among ...
Functions of the DEAH-box helicase DHX36 in type I interferon signaling
(2023-01-06)
The induction of type I interferons (IFN) is a hallmark of foreign nucleic acids immune sensing by the innate immune system. Based on the universal molecular structure of DNA and RNA throughout all kingdoms of life, the ...
PML and its degradation by arsenic trioxide in interferon-mediated neuro-inflammation
(2023-02-06)
Activation of interferon type-I (IFN-I) production and downstream signaling pathways mediate the tissue response to pathogens such as viruses, but its aberrant activation has been suggested to contribute to the aging process ...
Pharmacologic intervention in macrophage metabolism: Mitochondrial pyruvate carrier inhibition by Mitoglitazone modulates inflammation
(2023-08-09)
Upon Toll-like receptor (TLR) activation, macrophages rapidly change their transcriptional- and translational network and rewire their metabolism. Mitochondrial pyruvate import via the mitochondrial pyruvate carrier (MPC) ...