Dual-mode cholinesterase inhibitors targeting muscarinic receptors

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Author
Elsinghorst, Paul Wilhelm
Type of Scholarly Publication
Dissertation
Date of Exam
26.01.2007
Date of Publication
2007
Advisor
Gütschow, Michael
Co-Referee
Gündisch, Daniela
Involved Institutions
Rheinische Friedrich-Wilhelms-Universität Bonn
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Abstract
A gallamine-tacrine dimer and related analogues are presented. These compounds act as dual-mode cholinesterase inhibitors and additionally as allosteric modulators of muscarinic M2 receptors. Next to their synthesis, detailed kinetic and docking investigations are described to characterize these highly potent compounds.
Classification (DDC)
540 Chemie
Elsinghorst, Paul Wilhelm: Dual-mode cholinesterase inhibitors targeting muscarinic receptors. - Bonn, 2007. - Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn.
Online-Ausgabe in bonndoc: https://nbn-resolving.org/urn:nbn:de:hbz:5N-09567
@phdthesis{handle:20.500.11811/3050,
urn: https://nbn-resolving.org/urn:nbn:de:hbz:5N-09567,
author = {{Paul Wilhelm Elsinghorst}},
title = {Dual-mode cholinesterase inhibitors targeting muscarinic receptors},
school = {Rheinische Friedrich-Wilhelms-Universität Bonn},
year = 2007,
note = {A gallamine-tacrine dimer and related analogues are presented. These compounds act as dual-mode cholinesterase inhibitors and additionally as allosteric modulators of muscarinic M2 receptors. Next to their synthesis, detailed kinetic and docking investigations are described to characterize these highly potent compounds.},
url = {https://hdl.handle.net/20.500.11811/3050}
}

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