Fakultäten der Universität Bonn: Suche
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Essential and complementary function of dendritic cell subsets during immunotherapy
(2020-03-11)
T lymphocytes are critical components of the adaptive immune system that protects us against a variety of infections. However, during chronic infections such as with HIV, HCV and HBV as well as cancers, T cells become ...
Shedding light on the role of cAMP in mammalian sperm physiology
(2018-06-15)
Mammalian fertilization relies on sperm finding the egg and penetrating the egg vestments. All steps in a sperm's lifetime crucially rely on changes in the second messenger cAMP (cyclic adenosine monophosphate). In recent ...
Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors
(2019-11-14)
The second messenger 3´, 5´-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil ...
How to control cyclic nucleotide signaling by light
(2017-03-10)
Optogenetics allows to non-invasively manipulate cellular functions with spatio-temporal precision by combining genetic engineering with the control of protein function by light. Since the discovery of channelrhodopsin has ......
Radiometalle in der nuklearmedizinischen Anwendung: Prozessentwicklung und Translation in die klinische Routineanwendung
(2022-04-20)
In der vorliegenden Arbeit wurden mehrere Aspekte der täglichen radiopharmazeuti-schen Arbeit in der Nuklearmedizin bearbeitet. Der Fokus lag dabei auf der Translation von neuen Tracern aus der Forschung in die klinische ...
Interplay between the amyloid precursor protein (APP) and α-secretases at the plasma membrane
(2022-04-21)
Alzheimer’s disease (AD) is the most common form of dementia. A principle pathological feature of AD are senile plaques consisting of extracellular aggregations of amyloid β peptides (Aβ). Aβ is derived from the amyloid ...
Nemertean Systematics: Usefulness of DNA Barcoding and DNA Taxonomy for Species Identification, Delimitation, and Population Analyses
(2022-04-21)
The assessment of phylogenetic relationships and systematics of all metazoan taxa heavily relies on the accurate identification and delimitation of species. For the past two centuries, both species identification and ...
Fatty liver disrupts homeostatic functions of Kupffer cells in liver regeneration
(2022-04-22)
Obesity-associated liver disease represents a continuously increasing health concern. Besides the risk of obese individuals towards liver dysfunction, cirrhosis and hepatocellular carcinoma, an increased risk for defective ......
Einfluss der zellspezifischen Deletion des miR-17~92-Clusters auf die Entwicklung des Kleinhirns
(2022-06-28)
Seit der Entdeckung der ersten micro-Ribonukleinsäure (miRNA/miR) wurde intensiv an der Funktion von miRNAs bei der Entwicklung des Kleinhirns geforscht. Dennoch sind die Mechanismen, über die miRNAs die beteiligten ...
Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy
(2022-07-07)
Memory deficits are one of the most debilitating and common symptoms of temporal lobe epilepsy. However, so far, little is known about mechanisms underlying cognitive deficits and how pharmacologically target them. In most ...