Faculties of University Bonn: Search
Now showing items 11-20 of 866
Investigation of the in vivo Lysosomal Proteome Changes in Different Starvation Periods
(2021-04-09)
Nutrient deprivation can change the activity and subcellular localization of a protein. The cellular response to starvation includes the autophagy/lysosomal degradation pathway and the nutrient signaling pathway via the ......
External Control of Many-Body Quantum Systems
(2021-10-05)
In strongly correlated many-body quantum systems, the complex interplay between a large number of degrees of freedom and the presence of various competing energy scales leads to rich phase diagrams, but also renders these ...
Characterization of Mesenchymal Stromal Cells for Musculoskeletal Disorders and Regenerative Medicine
(2021-05-31)
Recently, mesenchymal stromal cells (MSC) have come increasingly into focus as a therapeutic option for bone pathologies and regenerative medicine. While human MSCs have been extensively characterized and standardized, ...
Einsatz der HIV-Postexpositionsprophylaxe im klinischen Alltag am Beispiel der Bonner HIV-Ambulanz
(2021-01-26)
Hintergrund: Die HIV Postexpositionsprophylaxe (PEP) ist etablierter und empfohlener Standard nach beruflicher Exposition (BE) oder nicht-beruflicher HIV-Exposition (NBE, sexuell). Publizierte Daten zur Expositionsart, ...
Faster Circuits for And-Or Paths and Binary Addition
(2020-07-24)
We consider the problem of constructing fast circuits both for binary addition and And-Or paths. And-Or paths are Boolean functions of the form t0 ∧ ( t1 ∨ ( t2 ∧ ( t3 ......
Don't Blame Developers! Examining a Password-Storage Study Conducted with Students, Freelancers, and Company Developers
(2020-12-11)
Authentication systems are a major concern for the usable security and privacy community. Twenty years ago, the seminal work “Users Are Not The Enemy” [1] by Adams and Sasse initiated a user-centred approach to research. ...
Synthese und Reaktionen von phosphorfunktionalisierten 1,3-Dithiol-2-thionen
(2021-01-05)
Die Dissertation "Synthese und Reaktionen von phosphorfunktionalisierten 1,3-Dithiol-2-thionen" beschreibt die Darstellung von tricyclischen 1,4-Dihydro-1,4-diphosphininen, die 1,3-Dithiol-2-thion-Einheiten tragen. Zugleich ...
Network effects of eslicarbazepine in the hippocampus
(2020-05-18)
Nearly 50 million people worldwide suffer from epilepsy, with 1/3 of the patients remaining without seizure control. This high number emphasizes the importance to develop new anti-epileptic drugs (AEDs) and to understand ...
Biochemical characterization of the human Cyclin-dependent kinases Cdk7 and Cdk10
(2021-08-13)
Protein kinases comprise a large superfamily of enzymes regulating a plethora of cellular processes. Dysregulation of protein kinases, such as loss of activity, hyperactivity or mislocalisation, is often accompanied with ...
Development of Computational Methods for Rationalizing Chemical Lead Optimization and Compound Design
(2021-09-22)
Chemical lead optimization (LO) plays an important role in pharmaceutical drug discovery. It represents a highly complex multi-objective process, in which the ultimate goal is to identify a suitable candidate molecule that ...