Faculties of University Bonn: Fakultäten der Universität Bonn: Recent submissions
Now showing items 101-120 of 9517
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Chemical Language Models for Molecular Design
(2025-08-06)In drug discovery, chemical language models (CLMs) inspired by natural language processing (NLP) provide innovative solutions for molecular design. CLMs learn the vocabulary, syntax, and conditional probabilities of molecular ... -
Machiavellistische Rollenerwartungen am Arbeitsplatz: Entwicklung und Validierung einer neuen Skala zur Erfassung der aus Mitarbeitendenperspektive wahrgenommenen machiavellistischen Erwartungen von Vorgesetzten
(2025-08-05)Die Arbeitsrolle von Mitarbeitenden ist maßgeblich durch die Erwartungen ihrer Vorgesetzten definiert. Nach der Rollentheorie (Katz & Kahn, 1978) spiegeln sich individuelle Persönlichkeitseigenschaften der Vorgesetzten in ... -
Expressionsmodulation der Hitzeschockproteine HSP27 und HSP70 in malignen Zellen nach Exposition gegenüber nicht-invasivem physikalischem Plasma
(2025-08-05)Aufgrund seines vor allem wachstumshemmenden Effekts auf maligne Zellen gilt Nicht-invasives physikalisches Plasma (NIPP) als vielversprechende Therapieoption in der Onkologie. <br/> Aktuelle Studien konnten eine Beteiligung ... -
Reproduzierbarkeit der quantitativen Auswertung der PSMA-PET
(2025-08-05)<strong>Hintergrund:</strong> Bei Patienten mit Prostatakarzinom, die eine PSMA-gerichtete Radioligandentherapie (RLT) erhalten, korrelieren höhere SUV-Werte mit besseren Therapieergebnissen. Daher ist es entscheidend, die ... -
Investigation and discovery of targetable markers in urological tumors
(2025-08-05)Urological cancers are among the cancers with the highest incidence. In recent years, several therapeutic solutions have been suggested and accepted in the clinic for treatment, but tumors, especially the most aggressive ... -
AIM2-Inhibitory Nanobodies Reveal Differential Activation of AIM2 and NLRP3 Inflammasomes by Poxvirus DNA Genomes in Primary Human Cells
(2025-08-05)Poxviruses are large double-stranded (ds)DNA viruses that replicate in the cytoplasm. While variola virus (VARV) caused millions of deaths before its eradication in 1980, monkeypox virus (MPXV) has been declared a public ... -
New perspectives on semi-parametric and pseudo-value approaches for modeling clinical time-to-event data
(2025-08-04)Clinical decision-making often relies on quantitative measures derived from statistical time-to-event models, enabling risk assessment through the quantification of survival probabilities. A key goal of these modeling ... -
A regulatory duet: sHdrR and SoxR team up for transcriptional repression of sulfur oxidation in Hyphomicrobium denitrificans
(2025-08-04)The Alphaproteobacterium <em>Hyphomicrobium denitrificans</em> X<sup>T</sup>, an obligately chemoorganoheterotrophic methylotroph, uses C<sub>1</sub> compounds like methanol and also C<sub>2</sub> compounds for two purposes: ... -
Anfall und Epilepsie: Morphometrische Kurz- und Langzeitkorrelate im mesialen Temporallappen
(2025-08-04)Epilepsie zählt zu den häufigsten chronischen neurologischen Erkrankungen, wobei die mesiale Temporallappenepilepsie (mTLE) die häufigste Form therapieresistenter Anfälle bei Erwachsenen darstellt. Die häufigste ... -
Biosynthesis of the corallorazines, a widespread class of antibiotic cyclic lipodipeptides
(2024-08-16)Corallorazines are cyclic lipodipeptide natural products produced by the myxobacterium <em>Corallococcus coralloides</em> B035. To decipher the basis of corallorazine biosynthesis, the corallorazine nonribosomal peptide ... -
Evaluating Bard Gemini Pro and GPT-4 Vision Against Student Performance in Medical Visual Question Answering: Comparative Case Study
(2024-12-17)<strong>Background:</strong> The rapid development of large language models (LLMs) such as OpenAI's ChatGPT has significantly impacted medical research and education. These models have shown potential in fields ranging ... -
Efficacy of Virtual Preparation Simulators Compared to Traditional Preparations on Phantom Heads
(2024-08-14)Background: Virtual simulators are increasingly being introduced in dental education. This study investigates whether virtual simulators offer comparable or superior educational efficacy when compared to traditional phantom ... -
Associations Between Clinical Factors and Postoperative Thrombosis in Pediatric Cardiac Surgery Patients: A Single-Center Retrospective Study
(2024-10-21)<strong>IMPORTANCE:</strong> Postoperative thrombosis is a significant complication in pediatric cardiac surgery patients, contributing to morbidity and mortality. Identifying clinical factors associated with thrombosis ... -
Schistosomiasis endemicity and its role in sexually transmitted infections: A systematic review and meta-analysis
(2024-09-02)<strong>Introduction:</strong> Schistosomiasis, a tropical parasitic disease, affects 779 million people globally, with 85% of cases in Africa. The interplay between schistosomiasis and other sexually transmitted infections ... -
Therapeutic alliance in individual adult psychotherapy: A systematic review of conceptualizations and measures for face-to-face- and online-psychotherapy
(2024-06-27)<strong>Background:</strong> The therapeutic alliance (TA) is a robust and pantheoretical predictor of treatment outcome in Face-to-Face- (F2F-) and Online-psychotherapy (Online-PT). Many authors have proposed several ... -
Understanding tissue-resident macrophages unlocks the potential for novel combinatorial strategies in breast cancer
(2024-07-22)Tissue-resident macrophages (TRMs) are an integral part of the innate immune system, but their biology is not well understood in the context of cancer. Distinctive resident macrophage populations are identified in different ... -
The role of the food environment as a driver of diet quality in children and adolescents: A cross-sectional analysis of external and individual factors
(2025-08-01)The food environment, typically considered the place where individuals interface with food supply, is increasingly discussed for its role and opportunity to influence diet quality of individuals. Available studies suggest ... -
Auswirkung der Lagerungsdauer von Erythrozytenkonzentraten auf den Anstieg der Hämoglobin-Konzentration nach Transfusion: Eine Subgruppen-Analyse der LIBERAL-Studie
(2025-08-01)Die LIBERAL-Studie ist eine DFG geförderte, prospektive, randomisierte, multizentrische, kontrollierte, klinische Phase-IV-Studie, an der 2.470 ältere Patienten teilnehmen, die sich einer nicht-herzchirurgischen Operation ... -
The role of root suberin in protecting barley plants from copper stress
(2025-08-01)Copper (Cu) contamination in agricultural soil significantly threatens crop growth, yield, and overall agricultural productivity. Although barley (<em>Hordeum vulgare</em> L.) exhibits a relatively high tolerance to metal ... -
Investigating the Role of Descending Neurons in Freely Flying Drosophila melanogaster
(2025-08-01)Understanding how neural circuits generate complex behaviors remains a central challenge in neuroscience. This thesis investigates the neural basis of flight control in <em>Drosophila melanogaster</em>, focusing on how ...
