The Faculty of Medicine: Search
Now showing items 101-110 of 182
Research to explore Intersectoral Collaborations for One Health Approach (RICOHA): A health system study in Ahmedabad, India
(2021-01-25)
The One Health (OH) approach is becoming popular across the globe, and some countries are underway to implement it. For the effective implementation of OH, the operationalization of intersectoral collaboration (ISC) is ...
Nicht beeinflusst oder nicht beachtet? Neue Blickwinkel auf die kontraläsionale Hemisphäre bei Rasmussen-Enzephalitis: Eine morphometrische MRT-Studie
(2020-12-23)
Die Rasmussen-Enzephalitis ist eine durch unihemisphärische progressive Atrophie gekennzeichnete, autoimmun vermittelte Erkrankung des Gehirns. Obwohl die zugrundeliegende Pathologie als strikt auf eine Hemisphäre begrenzt ...
Endotheliale Mikropartikel bei Patienten mit Systemischem inflammatorischen Response Syndrom nach kathetergestützter Aortenklappenimplantation
(2021-07-29)
Diese prospektive klinische Studie untersuchte zwischen Januar und Juni 2013 bei 50 Patienten mit einer hochgradigen Aortenklappenstenose und hohem operativen Risiko das Auftreten eines Systemischen inflammatorischen ...
Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice
(2021-07-13)
Parkinson’s disease is one of the most common neurodegenerative diseases in the elderly population, with a pathophysiology linked to neuroinflammation, complement activation and oxidative damage. Soluble polysialic acid ...
Modelling melanoma control by immunotherapy and tissue-resident memory T cells using CRISPR/Cas9-based approaches
(2020-02-03)
In recent years, immunotherapy has demonstrated remarkable efficacy in the treatment of metastatic melanoma due to the development of T cell-based therapies such as checkpoint inhibitors or adoptive T cell transfer therapy ......
Characterisation of Extracellular Vesicles Released upon NLRP3 Activation and Their Impact on Bystander Cells
(2020-02-17)
Inflammasomes are cytosolic multi-protein complexes that assemble upon detection of danger signals of infectious or sterile origin. Activation of the NOD-like receptor NLRP3 results in activation of caspase-1, which ...
Investigating the molecular basis of human NLRP1 inflammasome activation
(2020-03-10)
Cytosolic sensor proteins like NLRP1 (NOD-like receptor containing a pyrin domain 1) play a fundamental role in mediating innate immunity. Upon activation they form signalling hubs that recruit the adaptor protein ASC ...
The role of T cell help in shaping Dendritic Cell function
(2020-02-07)
CD8+ T cell priming depends on antigen presentation by dendritic cells (DCs) and their capacity to communicate contextual cues associated with antigen acquisition. DCs often also require additional signals from ......
The role of cytohesins in the regulation of immune responses
(2020-02-17)
Cytohesins are guanine nucleotide exchange factors for adenosine diphosphate ribosylation factor (Arf) proteins and promote the switch of Arfs to the active GTP-bound form. Cytohesins have been shown in different in vitro ......
Impact of chronic liver inflammation on adaptive immune responses to viral infection
(2020-03-11)
A common complication in patients suffering from chronic liver inflammation and fibrosis is the enhanced susceptibility to viral infections and weak responses to vaccination, which are associated with significant co-morbidities. ...