The Faculty of Mathematics and Natural Sciences: Browsing Mathematisch-Naturwissenschaftliche Fakultät by Title
Now showing items 3783-3802 of 4324
-
Synthese, Modellierung und Evaluation supramolekularer 9,9’-Spirobifluoren-Rezeptoren zur Erkennung organischer Ammoniumionen
Hintze, Kim Julia (2017-09-27)Diese Dissertation befasst sich mit der experimentellen und quantenchemischen Untersuchung des Bindungsverhaltens supramolekularer 9,9’-Spirobifluoren-Rezeptoren gegenüber verschiedenen Aminosäureestern.
Dazu wurden ... -
Synthese, Ringöffnungs- und Deoxygenierungsreaktionen von Oxaphosphiran-Metallkomplexen
Albrecht, Carolin (2013-09-25)Im Fokus der vorliegenden Arbeit stand zunächst Studien zur Synthese neuer Oxaphosphirankomplexe der Metalle der 6. Gruppe sowie die Erweiterung der Li/Cl-Phosphinidenoidkomplexroute durch Einbeziehung der Metallkomplexe ... -
Synthese, Testung und 3D-QSAR von ABCG2-Inhibitoren
Willmes, Thomas (2021-08-09)Die Behandlung von Krebserkrankungen baut im Allgemeinen auf verschiedenen Säulen auf, wobei die Chemotherapie eine der wichtigsten Therapiemethoden darstellt. Ein häufiges Versagen der Chemotherapie beruht auf der ... -
Synthesen, Kristallstrukturen und Eigenschaften quaternärer Ortho- und Pyrophosphate der zwei- und dreiwertigen 3d-Übergangsmetalle
Litterscheid, Christian (2009-12-09)In der vorliegenden Arbeit wurden Untersuchungen an quaternären Phosphaten der 3d-Übergangsmetalle durchgeführt. Im ersten Teil lag der Schwerpunkt auf der Synthese und Charakterisierung von quaternären Orthophosphaten ... -
Syntheses and structure-activity relationships of novel P2X3 receptor antagonists
Rashed, Mahmoud Sayed Ahmed Mahmoud (2018-04-19)P2X3 receptors are ligand-gated ion channels activated by extracellular adenosine-5’-triphosphate (ATP). Activation of the P2X3 receptors has been linked to several pathophysiological conditions including inflammation and ... -
Synthesis and analysis of conformationally restricted ceramide analogs: (Synthese und Untersuchung konformativ fixierter Ceramidanaloga)
Wirtz, Jennifer (2008)Ceramide (e.g. (2S,3R,4E)-2-Octadecanoylamino-octadec-4-en-1,3-diol) is a structural component of membrane glycosphingolipids and sphingomyelin, and occurs in free form as well as bound to proteins in the human skin ...
-
Synthesis and biological evaluation of novel ligands for the cannabinoid-like orphan G protein-coupled receptors GPR18 and GPR55
Vu, The Hung (2018-09-26)GPR18 and GPR55 belong to the more than 100 orphan G protein-coupled receptors (GPCRs) whose natural signaling molecules remain unidentified. Both orphan GPCRs have some relations with the cannabinoid receptors CB1 ... -
Synthesis and characterisation of novel isoform-selective histone deacetylase inhibitors (HDACi) and HDACi-based multi-target ligands
Reßing, Nina Jacqueline (2022-04-26)In the quickly evolving field of epigenetic therapy, histone deacetylases (HDACs) have emerged as preferred targets for the treatment of cancer and other conditions such as viral infections, neurodegenerative disorders, ... -
Synthesis and Characterisation of wALAD Inhibitors and Novel ABAL Probes
Halls, Victoria Simone (2016-10-12)The here presented work comprises two projects with highly interdisciplinary topics in the chemical biology field. The development of novel small molecule ALAD inhibitors which might show their potential as novel antifilarial, ... -
Synthesis and reactions of Janus-type bis(NHCs), tuned by phosphorus bridges
Naz, Nabila Rauf (2021-02-15)Due to our first attempts to synthesize P-functional bis(NHCs),[6] we were aware of a problem if bis(thiones) were used. Therefore, the idea emerged to use bis(selones) instead. Herein, the synthesis of the first tricyclic ... -
Synthesis and structure-activity relationships of CD39 and CD73 inhibitors
Bi, Chunyang (2022-08-13)Ecto-nucleoside triphosphate diphosphohydrolase-1 (NTPDase1 or CD39) is a member of the membrane-bound ecto-nucleotidase family, which catalyzes the extracellular hydrolysis of pro-inflammatory ATP and pro-thrombotic ADP ... -
Synthesis and structure-activity relationships of α,β-methylene-ADP derivatives: potent and selective ecto-5-nucleotidase inhibitors
Bhattarai, Sanjay (2015-08-19)Ecto-5'-nucleotidase (ecto-5'-NT, eN, CD73, EC 3.1.3.5) is a member of the group of ecto-nucleotidases which dephosphorylate extracellular nucleotides. eN catalyzes the ... -
Synthesis of ganglioside and lysoganglioside lipoforms as internal standards for MS quantification
Gantner, Martin (2015-01-08)The goal of this work was to establish methods for the synthesis of modified gangliosides that are suitable as internal standards for mass spectrometry. Quantification of gangliosides is usually achieved by staining after ... -
Synthesis of ligands for self-assembly of discrete metallo-supramolecular complexes
Hytteballe, Sophie (2016-02-22)Different aspects of self-assembly and self-sorting of metallo-supramolecular have been investigated in this thesis. Starting with self-sorting, four different 9,9'-spirobifluorene derivatives substituted with pyridine ... -
Synthesis, Characterization and Reactivity of Ylidyne and μ-Ylido Complexes Supported by Scorpionato Ligands
Ghana, Priyabrata (2018-02-21)The chemistry of compounds featuring triple bonds of the heavier Group-14 elements Si–Pb with transition metals is a very challenging research area, which combines modern molecular main-group element with transition-metal ... -
Synthesis, Crystallography and Spectroscopy of dinuclear Gold(I) NHC Macrocycles
Kobialka, Stefanie (2015-05-11)The synthesis, crystallography and spectroscopy of seven systematic series of dinuclear coinage metal(I) NHC complexes are shown here. As counter ions, bromide and the bulkier hexafluorophosphate are studied. Both gold(I) ... -
Synthesis, optimization, and characterization of chromen-4-one and 1,7-phenanthroline derivatives as ligands for the orphan G protein-coupled receptors 35 and 84
Wendt, Lukas Leopold (2021-06-21)G protein-coupled receptors (GPCRs) are ideal drug targets. Their characteristic tissue distribution, marked ligand specificity, and their roles in countless (patho)physiological processes are being exploited by more than ... -
Synthesis, reactions and redox properties of 1,4-dihydro-1,4-diphosphinines and related P/Si- and P/Ge-compounds
Kottayil Madam Ramachandran, Mridhul Ram (2023-11-16)This Ph.D. thesis describes the P-centered as well as other heteroatom-centered reactions of mixed-atom heterocyclic compounds.
Initially, the synthesis of the anionic imidazole-2-thione-fused 1,4-dihydro-1,4-diphosphinines ... -
Synthesis, structures and reactivity studies of P-bis(trimethylsilyl)methyl-substituted σ3λ3-oxaphosphirane complexes
Marinas Pérez, Janaina (2011-01-24)This thesis was focused on the investigations of the scope and limitations of the new method of synthesis of oxaphosphirane complexes of the group 6 metal triade based on recently discovered Li/Cl phosphinidenoid complexes. ... -
Synthesizing Human Motions
Krüger, Björn Peter (2012-04-05)In this work different data-driven methods for the synthesis of natural human full body motions are presented. My research in this area was based on the following fundamental questions: Suppose we have all the motion capture ...