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Evaluation of Striatin as a novel Microtubule Modulator
(2023-04-13)
The dynamics of the cell cycle and cell division are governed by tubulin polymers, i. e. microtubules (MTs). Defects of MT assembly or disassembly lead to pathogenic cellular conditions, negatively affecting cell viability, ......
Weiterentwicklung und Optimierung der Kontrolle der geschlossenen Gleichgewichtsbahn und des Modells der Elektronen-Stretcher-Anlage ELSA
(2023-04-17)
An der Beschleunigeranlage ELSA am Physikalischen Institut der Universität Bonn werden gegenwärtig zwei Experimente betrieben, welche die innere Struktur der Nukleonen untersuchen. ELSA zeichnet sich insbesondere durch die ...
GPR183 controls spatial organization and survival of hepatic conventional dendritic cells within hepatic portal regions via M-CSF and Gas6
(2023-04-19)
G protein-coupled receptor 183 (GPR183) recognizes 7α,25-dihydroxycholesterol (7α,25-OHC) and exerts chemotactic action upon recognition. Recent studies have shown that GPR183 is highly expressed in T, B and dendritic cells ...
Contesting Rural Futures: Political and Agrarian Change in Tanzania's Kilombero Valley during the Presidency of John P. Magufuli (2015 - 2021)
(2023-06-19)
The Arusha Declaration, written by the state founder Julius Nyerere in 1967, was replaced around the year 2000 by a new national development vision, Vision 2025. State visions of the future of the nation on the one hand ...
Next-Generation Electronics for the Read-Out of Micro-Pattern Gaseous Detectors
(2023-04-20)
Developed by the RD51 collaboration, the Scalable Readout System (SRS) is widely used for the read-out of Micro-Pattern Gaseous Detectors (MPGDs). With different front-end Application-Specific Integrated Circuits (ASICs) ...
Neuroanatomie und Funktionsmorphologie Peripherer Rezeptorneurone mit Direkten Projektionen in das Protocerebrum des Insektengehirns
(2023-04-20)
Zur Wahrnehmung unterschiedlicher thermischer Reize hat sich bei Insekten eine Reihe von Thermorezeptoren entwickelt. Der pyrophile („feuerliebend“) „Australische Feuerkäfer“ (Merimna atrata) besitzt paarige Infrarot-(IR)-Organe ......
Ectopic expression of transcription factors to overcome the lineage barrier between embryonic stem cells and trophoblast stem cells in mouse and human
(2023-04-19)
The placenta is a transient organ that exhibits various essential functions during pregnancy that allow for proper development of the embryo. Placenta and embryo originate from the first lineage separation in mammalian ...
Polymer-mediated solubility enhancement and supersaturation stabilization using various hydroxypropyl cellulose grades within amorphous solid dispersions
(2024-05-14)
Solubility enhancement in combination with supersaturation stabilization of poorly soluble drugs is a well-established concept to enhance oral bioavailability. One promising formulation principle to overcome low solubility ...
Human iPSC-derived in vitro models of the peripheral nervous system for cellular pain and somatosensation research
(2022-01-07)
The term 'somatosensation' summarizes the sensation of touch, body position, temperature and pain experienced by animals or humans. Peripheral sensory neurons can be classified according to their primary sensation as ...