Mathematisch-Naturwissenschaftliche Fakultät: Suche
Anzeige der Dokumente 1-10 von 61
Role of innate lymphoid cells in type 1-dominated experimental Plasmodium berghei ANKA and type 2-dominated Litomosoides sigmodontis infection
(2021-10-27)
Malaria and filariasis remain among the biggest health problems in the tropics and subtropics, especially in Africa, and in the case of malaria among the ten most frequent causes of death. The parasites that cause malaria ......
Single cell visual psychophysics
(2021-10-05)
On the one hand, the eye is the human being’s window to the world. On the other hand the eye is a window to the human brain enabling noninvasive and in vivo assessment of nervous tissue. With adaptive optics scanning laser ...
Etablierung und Anwendung unterschiedlicher kolorimetrischer Detektionsmethoden zur Aktivitätsbestimmung von Modulatoren der ABC-Transporter ABCB1, ABCC1 und ABCG2
(2020-10-29)
Die Überexpression von ABC-Transportproteinen in Krebszellen führt zu Resistenzen gegenüber einem großen Spektrum antineoplastischer Substanzen. ABCB1, ABCC1 und ABCG2 sind die wichtigsten Vertreter, welche zu dieser ...
Influence of disulfide-bonds on structural and functional properties of peptides and proteins - Case studies on FXIIIa inhibitor tridegin and µ-conotoxin PIIIA
(2021-05-28)
Disulfide-bonded peptides have been studied for many decades serving as tools to investigate various biochemical pathways as well as lead structures for drug development for numerous diseases. Among these, the most fatal ...
In Silico Facets of Biochemical Research: Accounts from Protein Folding and Protein-Ligand Interaction Studies
(2020-09-04)
Exponential advancements in computer technology over the last five decades have ubiquitously benefited science and humanity as a whole. Consequent beneficiaries of this surge of computational power include all subfields ......
Control of ion and neurotransmitter homeostasis by hippocampal astroglial networks
(2020-12-16)
The present study addressed the contribution of astrocytic gap junction channels to extracellular K+ clearance. Astrocyte form large networks through gap junction coupling that enables intercellular communication ...
CD8 T cell responses during primary and secondary influenza infection - Role of MHC-I expression on non-immune cells
(2021-09-03)
Influenza infection results in strong immune responses in the lung usually leading to clearance of infection and, in some cases, immune pathology with varying degrees of prognosis. CD8 T cells are believed to be one of the ...
Mapping the immune landscape in the alveolar space reveals alterations of multiple macrophage states in chronic obstructive pulmonary disease
(2021-03-26)
Chronic obstructive pulmonary disease (COPD) is ranked among the three leading causes of death worldwide and hence constitutes a significant burden, both medically and financially. The disease is characterized by a poorly ...
Structural aspects of the plasmalemmal Amyloid Precursor Protein cluster
(2021-11-12)
Alzheimer’s Disease (AD) is a major socio-economic threat to health care systems and society in general. Involvement of the amyloid-beta peptide (Aβ) and its parent, the amyloid precursor protein (APP), in AD seemed obvious ...
Aufklärung des zentralen Kohlenstoff- und Energiemetabolismus des Darmbakteriums Prevotella copri
(2020-06-19)
Die vorliegende Arbeit befasste sich mit dem zentralen Kohlenstoff- und Energiemetabolismus von Prevotella (P.) copri, eines der relevantesten Bakterien der menschlichen Darmflora. Um zu verstehen, wie die Prädominanz ......