Mathematisch-Naturwissenschaftliche Fakultät: Suche
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The Role of NMDA Receptor Co-Agonists in Dendritic Integration
(2021-03-26)
The integration of synaptic inputs is the fundamental function of neurons. This integration does not only take place at the soma, but also dendrites can actively shape the input-output computations of a neuronal network. ...
The influence of environmental UVB radiation on growth, immunity, behavior and sexually selected traits in the three-spined stickleback (Gasterosteus aculeatus)
(2020-07-13)
Changing photic conditions are, next to global warming, the major aspect in terms of ongoing global climate change and mainly occur within the short-wave and high-energetic ultraviolet-B (UVB) part of the electromagnetic ...
Mapping the immune landscape in the alveolar space reveals alterations of multiple macrophage states in chronic obstructive pulmonary disease
(2021-03-26)
Chronic obstructive pulmonary disease (COPD) is ranked among the three leading causes of death worldwide and hence constitutes a significant burden, both medically and financially. The disease is characterized by a poorly ...
Analyse des Lon Einflusses auf die Hitze-induzierte Aggregation mitochondrialer Proteine und auf die Bildung von Aggregatablagerungen
(2020-07-13)
Die mitochondriale Matrix Protease Lon ist ein essentieller Bestandteil des mitochondrialen Protein Qualitätskontroll-Systems. Der Verlust von Lon führt zu einer erhöhten Apoptoserate und embryonaler Letalität im Mausmodell. ...
Structural aspects of the plasmalemmal Amyloid Precursor Protein cluster
(2021-11-12)
Alzheimer’s Disease (AD) is a major socio-economic threat to health care systems and society in general. Involvement of the amyloid-beta peptide (Aβ) and its parent, the amyloid precursor protein (APP), in AD seemed obvious ...
Functional analysis of the endocannabinoid system in conditional mouse mutants
(2020-09-04)
In the scope of this thesis conditional knockout mice with a cell-specific deletion of Dagla (diacylglycerol lipase alpha) in neurons, astrocytes or microglia cells were generated, in order to identify the cellular source ...
Aufklärung des zentralen Kohlenstoff- und Energiemetabolismus des Darmbakteriums Prevotella copri
(2020-06-19)
Die vorliegende Arbeit befasste sich mit dem zentralen Kohlenstoff- und Energiemetabolismus von Prevotella (P.) copri, eines der relevantesten Bakterien der menschlichen Darmflora. Um zu verstehen, wie die Prädominanz ......
Langerhans and inflammatory dendritic epidermal cells in atopic dermatitis tolerate Toll-like receptor 2-specific activation
(2021-01-26)
Atopic dermatitis (AD) is a chronic multifactorial inflammatory skin disease. The skin of AD patients shows a significant dysbalance of the microbiome with high colonization of S. aureus, which positively correlates with ...
State-dependent processing of Dentate Gyrus granule cell activity in-vivo
(2020-12-16)
The ability to form dissimilar neural activity patterns from similar sensory driven inputs is a phenomenon found in all vertebrates, called pattern separation. In mammals, pattern separation is closely related to a subregion ...
The influence of G-quadruplex structures on meiosis
(2021-01-27)
Several lines of evidence emphasize the potential function of G-quadruplex (G4) structures during DNA replication, transcription and recombination. Although there are experimental evidences that G4s play a role during ......