The Faculty of Mathematics and Natural Sciences: Search
Now showing items 21-30 of 40
Investigation of the procoagulant role of labile heme under hemolytic conditions
(2021-07-19)
Severe intravascular hemolysis leads to the excessive release of labile heme into the vascular compartment, thereby overwhelming the heme-binding capacity of the protective heme- scavenging system. As a consequence, labile ...
Structural and functional characterization of TRAP transporters from bacterial pathogens
(2021-08-26)
The class of tripartite ATP-independent periplasmic (TRAP) transporter proteins are wide-spread in the kingdoms of prokaryotes and archaea, where they are responsible for translo-cation of substrates across the cell membrane. ......
Beeinflussung (steriler) entzündlicher Prozesse in Makrophagen durch lysosomotrope Arzneistoffe
(2021-05-14)
Inflammatorische Reaktionen und chronische Entzündungen sind mitunter die Hauptfaktoren für das Auftreten von Erkrankungen wie Psoriasis, rheumatoider Arthritis oder Morbus Crohn, wobei zahlreiche Komponenten des Immunsystems ......
Die Implementierung des Themas Fernerkundung in den Schulunterricht der Sekundarstufe I durch das neue MINT-Wahlpflichtfach "Geographie-Physik": eine Studie zur praktischen Schulfachgestaltung im Differenzierungsbereich der Jahrgangsstufen 8 und 9 an Gymnasien in Nordrhein-Westfalen am Beispiel des Gymnasiums Siegburg Alleestraße
(2021-10-26)
Schülerinnen und Schüler werden in ihrer Alltagswelt seit dem letzten Jahrzehnt immer früher mit Satellitenbildern konfrontiert. Durch den Wetterbericht und die Nachrichtensendung im Fernsehen oder durch virtuelle Globen ...
Mechanisms of epileptogenesis in animal models of developmental brain lesions
(2021-11-05)
Developmental brain lesions, including glioneuronal tumors (GNT) and malformations of cortical development (MCD), are among the most common causes for pharmaco-resistant epilepsy. Despite substantial differences, their ...
Investigating 5-HT2A receptors - Development of a fluorescent 5HT2A receptor agonist and elucidation of the effects of St. John's wort extract STW3-IV, hyperforin and hyperoside on 5HT2A receptors
(2021-09-22)
Investigating 5-HT2A receptors - Development of a fluorescent 5HT2A receptor agonist and elucidation of the effects of St. John's wort extract STW3-IV, hyperforin and hyperoside on 5HT2A ...
Molecular pharmacological analysis of the human MrgD receptor: New insights into signaling
(2021-08-09)
Introduction: MrgD is a member of the MAS-related GPCRs family. It has been proposed to play roles in nociception and cardiovascular control. MrgD has been shown to couple to Gq, Gi, and Gs proteins. The ...
Contributions towards a better understanding of millipede phylogenetics and sawfly genomics
(2021-03-11)
A loss of biodiversity on a scale and rate comparable to the great extinction events, as a result of anthropogenic activity, has been documented for plants, animals, and micro-organisms. In order to foster a sustainable ...
Modulation der Gαi1/s-Proteinaktivität durch lineare und makrozyklische Peptide
(2021-07-08)
Die vorliegende Dissertation beschäftigt sich mit der Identifizierung und Charakterisierung von peptidischen Modulatoren für die Gαi/s-Proteinaktivität. Die Ga-Untereinheit heterotrimerer G-Proteine ist eine bedeutende ...
Hippocampal network and inhibitory neuron dysfunction in age and disease
(2021-10-25)
Aging and Alzheimer’s disease (AD) are two highly intertwined pathological processes. Indeed, one of the highest risk factors for developing AD is age. Mechanistically, it has been suggested that remodeling of inhibitory ......