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Inhibitory Circuits of the CA3-Dentate Gyrus System
(2021-11-04)
Neuronal inhibition is an essential feature of all brain areas. Besides controlling the average rate of neuronal firing, it also controls the precise timing of action potentials and mediates several types of network ...
Optimierung und Charakterisierung eines Zwei-Photonen-Besselstrahl-Lichtscheibenmikroskops
(2021-05-10)
In dieser Arbeit wurde ein existierendes konfokales Zwei-Photonen-Lichtscheibenmikroskop charakterisiert und modifiziert. Das System wurde sowohl für Aufnahmen bei hohen Geschwindigkeiten als auch für Langzeitaufnahmen ......
Synthese, Testung und 3D-QSAR von ABCG2-Inhibitoren
(2021-08-09)
Die Behandlung von Krebserkrankungen baut im Allgemeinen auf verschiedenen Säulen auf, wobei die Chemotherapie eine der wichtigsten Therapiemethoden darstellt. Ein häufiges Versagen der Chemotherapie beruht auf der ......
Synthesis, Investigation and 3D-QSAR Analysis of ABCG2 Inhibitors
Cancer is one of the main causes of death worldwide. Despite the significant development of methods of cancer healing during the ......
Synthesis, Investigation and 3D-QSAR Analysis of ABCG2 Inhibitors
Cancer is one of the main causes of death worldwide. Despite the significant development of methods of cancer healing during the ......
Funktionelle Untersuchungen des ABC-Transporters ABCG2
(2021-10-15)
Das Phänomen der Multidrug Resistance (MDR) stellt ein bedeutsames Problem bei der Behandlung von Tumoren mit Chemotherapeutika dar. Die ABC-Transporter ABCB1, ABCC1 und ABCG2 sind an der Entstehung der MDR beteiligt. ...
The Impact of CD44 and Osteopontin on Hematopoiesis
(2021-10-25)
Hematopoiesis is the process, which enables the replenishment of blood cellular components in mammals throughout their lifespan. Hematopoietic stem cells (HSC), which reside within the bone marrow (BM), are the primary ...
Electrostatic anchoring of SNAP25 to the plasma membrane
(2021-07-21)
Neurotransmission is based on incredibly rapid membrane trafficking cycles, mediating the release of neurotransmitters. The fusion machinery of the well-studied SNARE protein complex ensures the speed and precision of ...
Twin-screw Melt Granulation as alternative Granulation Strategy
(2021-07-28)
Melt granulation is an interesting alternative technique to produce both, immediate and controlled-release final products using twin-screw extruders. The aim of this current work was to gain a deeper understanding of the ...
Synthesis, optimization, and characterization of chromen-4-one and 1,7-phenanthroline derivatives as ligands for the orphan G protein-coupled receptors 35 and 84
(2021-06-21)
G protein-coupled receptors (GPCRs) are ideal drug targets. Their characteristic tissue distribution, marked ligand specificity, and their roles in countless (patho)physiological processes are being exploited by more than ...
Medicinal chemistry and molecular pharmacology of orphan human Mas-related G protein-coupled receptors X2 and X4 (MRGPRX2 and MRGPRX4)
(2021-10-19)
The MRGPRX protein subfamily comprise rhodopsin-like orphan GPCRs, whose endogenous agonists have not been identified yet. They are exclusively expressed in primates, including humans. All Mas-related GPCRs (MRGPRs) were ...
The chromatin organizer Satb1 regulates the differentiation into CD4+ TH subsets and is essential for the development of TH17 cells
(2021-06-04)
CD4+ T cells play a critical role in host defense and tissue homeostasis. Upon encountering their specific antigen, naive CD4+ T cells can differentiate into the effector T helper (TH) subsets ...