Mathematisch-Naturwissenschaftliche Fakultät: Suche
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Multi-View Kernel Methods for Binding Affinity Prediction
(2021-09-27)
In the present thesis, we focus on the potential and limits of multi-view regression techniques in the field of ligand affinity prediction.
Multi-view learning (MVL) denotes machine learning approaches that utilise ...
Multi-view learning (MVL) denotes machine learning approaches that utilise ...
Langerhans and inflammatory dendritic epidermal cells in atopic dermatitis tolerate Toll-like receptor 2-specific activation
(2021-01-26)
Atopic dermatitis (AD) is a chronic multifactorial inflammatory skin disease. The skin of AD patients shows a significant dysbalance of the microbiome with high colonization of S. aureus, which positively correlates with ...
Improving solubility and supersaturation of poorly soluble drugs using solid dispersions based on natural polymers and mixtures thereof
(2021-05-19)
The poor solubility of existing drug substances and new chemical entities is a problem in modern pharmaceutical development. There are various strategies to overcome the solubility limited bioavailability of poorly soluble ...
Super-resolution time-resolved imaging using computational sensor fusion
(2021-01-18)
Imaging across both the full transverse spatial and temporal dimensions of a scene with high precision in all three coordinates is key to applications ranging from LIDAR to fluorescence lifetime imaging. However, compromises ...
The influence of G-quadruplex structures on meiosis
(2021-01-27)
Several lines of evidence emphasize the potential function of G-quadruplex (G4) structures during DNA replication, transcription and recombination. Although there are experimental evidences that G4s play a role during ......
Effect of neural ablation of sphingosine-1-phosphate lyase (SGPL1) in glial cells
(2021-11-24)
Sphingosine-1-phosphate (S1P) is an evolutionarily conserved catabolic intermediate of sphingolipid metabolism that regulates diverse biological processes in the brain, including neural development, differentiation, and ...
Design, Synthesis and Structure-Activity-Relationships of Potent Mas-Related G Protein-Coupled Receptor X (MRGPRX) Modulators
(2021-04-12)
The G protein-coupled receptor (GPCR) superfamily with more than 800 members is one of the most important target classes for drug development. After an agonist binds to the receptor, it induces a conformational change ......
Das Dreistoffsystem Europium / Phosphor / Sauerstoff: Phasenbestand, Gleichgewichtsbeziehungen und Charakterisierung der Phosphate mit Ergänzungen zum Redoxverhalten von EuPO4 gegenüber Übergangsmetallen
(2021-08-17)
Das ternäre System Europium / Phosphor / Sauerstoff
Die Reihe der thermodynamisch stabilen, wasserfreien Europium(III)-phosphate erstreckt sich vom "basischen" Oxidphosphat EuIII ...
Die Reihe der thermodynamisch stabilen, wasserfreien Europium(III)-phosphate erstreckt sich vom "basischen" Oxidphosphat EuIII ...
Comparative Analysis of Open Linked Fiscal Data
(2021-06-01)
The open data movement within public administrations has provided data regarding governance publicly. As public administrators and governments produce data and release the data as open data, the volume of the data is highly ...
Die digitale Neu-Vermessung touristischer Aktionsräume
(2021-12-21)
Das Wissen, wie sich Touristen zum und im Reiseziel bewegen, ist für eine nachhaltige Destinationsentwicklung unerlässlich geworden und hat durch die Covid-19-Pandemie und die damit zusammenhängende Notwendigkeit der ...