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Chemoinformatics-Driven Approaches for Kinase Drug Discovery
(2020-01-07)
Given their importance for the majority of cell physiology processes, protein kinases are among the most extensively studied protein targets in drug discovery. Inappropriate regulation of their basal levels results in ...
Mechanisms of epileptogenesis in animal models of developmental brain lesions
(2021-11-05)
Developmental brain lesions, including glioneuronal tumors (GNT) and malformations of cortical development (MCD), are among the most common causes for pharmaco-resistant epilepsy. Despite substantial differences, their ...
Evolution of the Activity Cliff Concept and Practical Implications for Compound Design
(2021-07-22)
Entering the “big data” era, a number of different research areas have witnessed an enormous increase in data at an exponential rate. For drug discovery, various publicly available protein structure and compound bioactivity ...
Hydroxylation of ectoine and synthetic ectoine derivatives via E. coli-mediated whole-cell biotransformation
(2021-06-07)
The compatible solutes ectoine and hydroxyectoine are compounds mainly produced by halophilic organisms in order to prevent the loss of intracellular water when exposed to high osmotic pressure. Furthermore, these substances ......
Unraveling TRIM71-mediated RNA regulatory mechanisms during developmental and oncogenic processes
(2020-05-18)
A dysregulation in the tight control of cell proliferation and differentiation severely affects developmental processes, and can lead to oncogenic transformation in the adult organism. The stem cell-specific protein TRIM71 ...
Characterization of cellular functions of the deubiquitinating enzyme OTUD4
(2020-08-10)
Post-translational modification of proteins with ubiquitin influences myriad of cellular processes by affecting protein stability, degradation, localization and protein-protein interactions. Ubiquitin gets transferred to ...
Phenotyping of barley resistance to plant diseases on the leaf and greenhouse scale through hyperspectral imaging and data analysis
(2021-05-17)
Optical sensors become increasingly interesting as means to perform automated, non-invasive and objective monitoring in agriculture, but also have immense potential as tools for research and development. Especially ...
A role of Alzheimer’s disease-associated γ-secretase in lipid metabolism and lipid droplet formation via LXR activation
(2021-06-29)
The γ secretase is an intramembrane protease complex, essential for the processing of a wide variety of type-1 membrane proteins. Among these is the amyloid precursor protein (APP), a protein strongly linked to Alzheimer’s ...
Investigating 5-HT2A receptors - Development of a fluorescent 5HT2A receptor agonist and elucidation of the effects of St. John's wort extract STW3-IV, hyperforin and hyperoside on 5HT2A receptors
(2021-09-22)
Investigating 5-HT2A receptors - Development of a fluorescent 5HT2A receptor agonist and elucidation of the effects of St. John's wort extract STW3-IV, hyperforin and hyperoside on 5HT2A ...
Characterization of the hyperpolarization-activated, highly-selective proton channel HCNL1 found in the sperm of the zebrafish Danio rerio
(2021-04-29)
Zebrafish are external fertilizers and release their gametes into the surrounding water. Yet, the freshwater environment with its low osmolarity poses a challenge for the gametes. Given these unique ion conditions, it seems ......
Charakterisierung des hyperpolarisationsaktivierten, hochselektiven Protonenkanals HCNL1 im Spermium des Zebrafischs Danio rerio
Zebrafische pflanzen sich durch externe Befruchtung fort und geben ......
Charakterisierung des hyperpolarisationsaktivierten, hochselektiven Protonenkanals HCNL1 im Spermium des Zebrafischs Danio rerio
Zebrafische pflanzen sich durch externe Befruchtung fort und geben ......