Mathematisch-Naturwissenschaftliche Fakultät: Suche
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OptoRiboGenetics: Post-transcriptional control of gene expression by light
(2021-08-26)
Gene expression is tightly regulated in mammalian cells at the post transcriptional level and its precise manipulation has proven to be valuable for protein overexpression and gene therapy. Implementation of light-responsive ......
OptoRiboGenetics - Posttranskriptionelle Kontrolle der Genexpression mit Licht
Die Genexpression von Säugetierzellen wird maßgeblich auf post-transkriptioneller Ebene reguliert und das Eingreifen auf ......
OptoRiboGenetics - Posttranskriptionelle Kontrolle der Genexpression mit Licht
Die Genexpression von Säugetierzellen wird maßgeblich auf post-transkriptioneller Ebene reguliert und das Eingreifen auf ......
Investigations into side chain assembly and attachment during biosynthesis of the G protein inhibitor FR900359
(2021-06-07)
The natural product FR900359 (FR) selectively inhibits Gaq proteins and thus intracellular signalling of many G protein-coupled receptors. This unique mechanism of action makes FR an indispensable pharmacological tool to ......
The Role of microRNAs in the Regulation of Human UDP-glucuronosyltransferases (UGTs)
(2021-06-14)
The liver is involved in endo- and xenobiotic metabolism due to the expression of drug-metabolizing UDP-glucuronosyltransferases (UGTs). By UGT-mediated elimination of hazardous compounds and other reactive metabolites, ...
Implementation and characterisation of click-SELEX targeting the chemokine CXCL9, for the development of a POC device for renal allograft rejection
(2021-11-04)
Renal allograft rejection is a serious medicinal condition, as appr. 25 % of the allografts are rejected. This medical disorder will lead to death of the patient if not treated early. Currently the gold standard to diagnose ...
Locus coeruleus modulates locomotor activity via the medial septum and the diagonal band of Broca
(2020-10-02)
The locus coeruleus (LC) is positioned in the brainstem and one of the main sources of norepinephrine in the brain. With its projections throughout the whole brain, the LC plays an important role in regulating the general ...
Application of BioID to in vitro organelle and in vivo cell-type-specific proteomics
(2020-09-17)
A genetically modified biotin ligase BirA (Arg118Gly), termed BioID (BirA*), can be induced to add a reactive form of biotin to proximate proteins in the cytosol and nucleus. The biotinylated proteins can be purified and ......
Optimierung der mikrobiellen Produktion von präbiotischen Zuckerderivaten auf Levan-Basis
(2021-04-21)
Die vorliegende Arbeit befasste sich mit der Entwicklung und Optimierung einer mikrobiellen Produktionsstrategie zur Synthese ß-2,6-glykosidisch verknüpfter Fruktane. Levan (ß-2,6-glykosidisch verknüpftes Fruktan) und ......
Untersuchungen zur heterologen Biosynthese des seltenen kompatiblen Soluts Nε-Acetyl-β-Lysin
(2020-08-28)
Das Aminosäurederivat Nε-Acetyl-β-Lysin (NAβL) wird von methanogenen Archaeen und einigen Vertretern der Bakterien zur Anpassung an osmotischen Stress produziert. Bisher wurden vor allem die zur Produktion ......
Studies on the heterologous biosynthesis of the rare compatible solute Nε-acetyl-β-lysine
The amino acid derivative Nε-acetyl-β-lysine (NAβL) is produced by methanogenic ......
Studies on the heterologous biosynthesis of the rare compatible solute Nε-acetyl-β-lysine
The amino acid derivative Nε-acetyl-β-lysine (NAβL) is produced by methanogenic ......
Generation of an RNA sensor to probe glycolysis in living cells via the key metabolite fructose 1,6-bisphosphate
(2021-06-24)
Glycolysis is the cornerstone of cell metabolism and is one of the oldest biochemical pathways known to life. Yet, methods to study glycolysis in single living cells are lacking. The glycolytic intermediate Fructose ...
Deciphering the functional role of the LIS1/NDEL1/14.3.3ε protein complex in the expansion of human cortical progenitors in an iPSC-derived organoid model
(2021-07-19)
The human brain is an exceptionally complex organ, both structurally and functionally, and represents the most remarkable progress in evolution. The human cortex is a highly organised and extensively folded structure ...