Sleep is a complex physiological process with a variety of molecules involved. Even though a lot of research and progress has been made until today, the exact underlying mechanism still eludes us. Many people must deal ...

Galaxies are the building blocks of the universe, which come in different sizes and shapes. Driven by dark matter, galaxies can interact and merge to form bigger galaxies across cosmic time. Across the cosmos, there are ...

Bacteria and bacteriophages are in a constant arms race to develop strategies to coexist. One adaptive defense system, which bacteria and archaea have developed against phages is the CRISPR-Cas (Clustered Regularly Interspaced ...

In this cumulative thesis, I present my research on transcriptomic-based drug repurposing in human viral infections describing an optimized workflow for drug prediction, <em>in vitro</em> validation and <em>in vivo</em> ...

We introduce a novel probabilistic framework for the solution of non-linear geophysical inverse problems in complex variables. By using complex probability distributions, this approach can simultaneously account for ...

This thesis is dedicated to the theoretical investigation of massive binary systems consisting of a normal star and a neutron star or black hole as a companion. The initial focus lies on the mass transfer from an evolved ...

Machine learning (ML) regression has a tremendous impact on advancing scientific progress. ML regression models predict continuous label values based on input features by leveraging large labeled datasets to learn the ...

Digital Silicon Photomultipliers (dSiPMs) and Monolithic Active Pixel Sensors (MAPS) are emerging technologies, fabricated using commercial Complementary Metal-Oxide-Semiconductor (CMOS) processes. These detectors have the ...

The pharmacometrics models, such as population (Pop) pharmacokinetic (PK) models, were developed to explain the variability in PK parameters of anti-infective drugs including cefiderocol cefepime, rifampicin, and remdesivir, ...

As cities in the Global South encounter increasingly complex urban landscapes shaped by environmental, socio-political, infrastructural, and health-related risks, governance challenges intensify. This thesis critically ...