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Rapid protection against viral infections by chemokine-accelerated post-exposure vaccination
(2024-01-29)<strong>Introduction:</strong> Prophylactic vaccines generate strong and durable immunity to avoid future infections, whereas post-exposure vaccinations are intended to establish rapid protection against already ongoing ... -
Physiochemical and mechanical characterisation of orthodontic 3D printed aligner material made of shape memory polymers (4D aligner material)
(2023-12-25)<em>Objectives:</em> To conduct a physiochemical and mechanical material analysis on 3D printed shape-memory aligners in comparison to thermoformed aligners.<br /> <em>Materials and methods:</em> Four materials were examined, ... -
Spirituality and anxiety in pastoral care workers and physicians in the first wave of the COVID-19 pandemic
(2024-03-11)<strong>Background:</strong> The COVID-19 pandemic had serious impact on the well-being of health care workers and highlighted the need for resources to help hospital staff to cope with psychologically negative consequences. ... -
Ripple-locked coactivity of stimulus-specific neurons and human associative memory
(2024-02-16)Associative memory enables the encoding and retrieval of relations between different stimuli. To better understand its neural basis, we investigated whether associative memory involves temporally correlated spiking of ... -
Obstetric Medicine: the protocol for a prospective three-dimensional cohort study to assess maternity care for women with pre-existing conditions (ForMaT)
(2024-01-11)<strong>Background:</strong> Pregnancies in women with pre-existing medical conditions are on the rise. These pregnancies are characterized by an increased rate of maternal and perinatal complications, which can result in ... -
Alpha modulation via transcranial alternating current stimulation in adults with attention-deficit hyperactivity disorder
(2024-01-12)<strong>Background:</strong> One potential therapy treating attention-deficit/hyperactivity disorder (ADHD) is to modulate dysfunctional brain activations using brain stimulation techniques. While the number of studies ... -
Evolving the Era of 5D Ultrasound?: A Systematic Literature Review on the Applications for Artificial Intelligence Ultrasound Imaging in Obstetrics and Gynecology
(2023-10-29)Artificial intelligence (AI) has gained prominence in medical imaging, particularly in obstetrics and gynecology (OB/GYN), where ultrasound (US) is the preferred method. It is considered cost effective and easily accessible ... -
Comparison between regular additional endobiliary radiofrequency ablation and photodynamic therapy in patients with advanced extrahepatic cholangiocarcinoma under systemic chemotherapy
(2023-08-29)<strong>Background and aims: </strong>Extrahepatic cholangiocarcinoma (eCCA) remains a malignancy with a dismal prognosis. The first-line standard of care includes systemic chemotherapy (SC) and biliary drainage through ... -
Neurogenic Lower Urinary Tract Symptoms, Fatigue, and Depression — Are There Correlations in Persons with Multiple Sclerosis?
(2023-08-04)The symptoms of multiple sclerosis (MS) frequently include fatigue, depression, and neurogenic lower urinary tract symptoms (LUTS), causing severe burdens on affected individuals. The relationships between these symptoms ... -
Effects of a video game intervention on symptoms, training motivation, and visuo-spatial memory in depression
(2023-08-24)<strong>Background:</strong> People with Major Depressive Disorder (MDD) often experience reduced affect, mood, and cognitive impairments such as memory problems. Although there are various treatments for MDD, many of them ... -
Sub-cone visual resolution by active, adaptive sampling in the human foveola
(2024-10-29)The foveated architecture of the human retina and the eye’s mobility enable prime spatial vision, yet the interplay between photoreceptor cell topography and the constant motion of the eye during fixation remains unexplored. ... -
Congenital Gerbode Defect: A Left Ventricular to Right Atrial Shunt: State-of-the-Art Review of Its General Data, Diagnostic Modalities, and Treatment Strategies
(2024-05-28)The congenital Gerbode defect is defined as an abnormal communication between the left ventricle and the right atrium. This review aimed to summarize existing evidence, shed light on the clinical implications, and identify ... -
Deficient immune response following SARS-CoV-2 vaccincation in patients with hepatobiliary carcinoma: A forgotten, vulnerable group of patients
(2023-05-10)<strong>Introduction:</strong> Data on immune response rates following vaccination for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in patients with hepatobiliary carcinoma (HBC) are rare. However, impaired ... -
Urinary and double incontinence in cognitively impaired patients: Impacts on those affected and their professional caregivers
(2023-05-09)Urinary or double incontinence in frail elderly people is common and leads to a reduction in quality of life and an increased burden on the patients’ caregivers. Up to now, no special instrument has been available to assess ... -
Cytokine Production of CD56bright Natural Killer Cells From Human Immunodeficiency Virus–Infected Individuals Under Effective Antiretroviral Therapy
(2022-09-01)Human immunodeficiency virus (HIV) infection is associated with impaired natural killer (NK) cell activity, which is only incompletely restored under antiretroviral therapy. Analyzing the bioenergetics profiles of oxygen ... -
Cell Cycle Regulation of G-Quadruplex DNA Structures at Telomeres
(2012-05-01)DNA and RNA regions containing tracts of guanines can form very stable secondary structures called G-quadruplex (G4). Genomic sequences with the potential to form G4 (G4-motifs) are abundant across species. In all analyzed ... -
Detecting G4 unwinding
(2022-04-18)DNA can, in addition to the B-DNA conformation, fold into a variety of additional conformations. Among them are G-quadruplex structures that have gained a lot of attention in recent years. G-quadruplex structures (G4s) are ... -
The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes
(2020-10-12)<em>DHX36</em> is a member of the DExD/H box helicasefamily, which comprises a large number of proteinsinvolved in various cellular functions. Recently, thefunction of DHX36 in the regulation of G-quadruplexes(G4s) was ... -
Cost-effectiveness and Quality of Specialized and Routine Care in a German Cohort of Patients with Chronic Pruritus
(2023-04-21)Chronic pruritus is a prevalent interdisciplinary symptom with a strong influence on health-related quality of life. Patients need extensive diagnostics and long-term treatment. This retrospective and prospective cohort ... -
Parameters Associated with the Required Drug Dose of Intravenous Immunoglobulin in Stable Chronic Inflammatory Demyelinating Polyradiculoneuropathy
(2023-03-10)Background: Intravenous immunoglobulin (IVIg) is efficient and one of very few treatment options for patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). However, finding the optimal dose of ...
