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Shedding light on the role of cAMP in mammalian sperm physiology

Balbach, Melanie; Beckert, Vera; Hansen, Jan N.; Wachten, Dagmar (2018-06-15)

Mammalian fertilization relies on sperm finding the egg and penetrating the egg vestments. All steps in a sperm's lifetime crucially rely on changes in the second messenger cAMP (cyclic adenosine monophosphate). In recent ...

Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors

Klausen, Christina; Kaiser, Fabian; Stüven, Birthe; Hansen, Jan N.; Wachten, Dagmar (2019-11-14)

The second messenger 3´, 5´-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil ...