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Role of the chemokines CCL17 and CCL22 in bacterial infection and IL-33-induced immune responses
(2023-11-24)The chemokines CCL17 and CCL22 are primarily expressed by dendritic cells (DC) and macrophages. Both chemokines share the receptor CCR4, which is expressed on DC and macrophages as well as on a variety of different T cell ... -
Role of the chemokines CCL17 and CCL22 in the immune defence against Salmonella infection
(2020-03-17)The chemokines CCL17 and CCL22 are both ligands of the chemokine receptor CCR4, which is expressed on dendritic cells (DC) and a variety of different effector T cells including regulatory T cells (Treg). Both chemokines ... -
The role of the endocannabinoid receptor CB2 in a mouse model of Alzheimer's disease
(2018-09-26)Over the past years, an important role of the cannabinoid receptor 2 (CB2) has been implicated in several neurological and immunological conditions, such as experimental autoimmune encephalitis, stroke, memory, neuropathic ... -
The role of the endocannabinoid system in brain and systemic ageing
(2024-01-15)Previous research from our laboratory has demonstrated that genetic manipulations leading to reduced CB1 receptor signaling in mice accelerated the ageing process. Specifically, the constitutive deletion of the CB1 receptor ... -
The role of the endocannabinoid system in stress-related disorders and neuroimmune communication
(2020-05-04)In the last decades, increasing evidence suggests that inflammatory processes play an important role in the development of psychiatric disorders, such as anxiety and depression. Psychosocial stress – one of the main ... -
The role of the Hippo pathway in etiology and progression of pancreato-biliary tumors and clear cell renal cell carcinoma
(2016-01-21)In the quest for the discovery of novel targets for cancer therapy, aberrantly reactivated embryonic signaling pathways have proven to be a rich mine and recent years have seen the introduction of the hedgehog-inhibitor ... -
The role of the miR-17-92 cluster in macrophage driven innate immunity
(2018-12-11)Research into miRNA, discovered in 1993, has exploded and revolutionized our understanding of molecular regulation in biological systems. MicroRNAs are now a well established as a regu- latory mechanism of many pathways ... -
Role of the proton channel HVCN1 in the regulation of neutrophil activation
(2023-06-22)(noch nicht zugänglich / not yet accessible) -
Role of the Receptor for Advanced Glycation End-products (RAGE) in the Immune Sensing of Nucleic Acids
(2016-09-06)Nucleic acid recognition is an important mechanism that enables the innate immune system to detect both microbial infection and tissue damage. To minimize the recognition of self-derived nucleic acids, all nucleic acid ... -
The role of the salvage pathway of phytol, geranylgeraniol, and farnesol phosphorylation in Arabidopsis thaliana
(2021-03-09)The isoprenoid alcohol phytol can be phosphorylated in Arabidopsis to phytyl-phosphate (phytyl-P) by the phytol kinase (VTE5) and further to phytyl-diphosphate (phytyl-PP) by the phytyl phosphate kinase (VTE6). Phytyl-PP ... -
The role of the stemness factor Nanog in cell cycle regulation
(2011-01-12)Pluripotency of embryonic stem (ES) cells is maintained through various extrinsic and intrinsic influences. In the center of intrinsic stemness signaling, a triad of transcription factors, namely Nanog, Oct3/4 and Sox2, ... -
The role of the transcription factor BCL11A in midbrain dopaminergic neurons
(2022-03-11)Midbrain dopaminergic (mDA) neurons are located in three midbrain nuclei, the substantia nigra (SN), ventral tegmental area (VTA) and retrorubral field (RRF). mDA neurons are diverse in their developmental origin, their ... -
The role of the zinc finger transcription factor Gli3 in murine hindbrain development
(2019-07-15)The zinc finger transcription factor GLI3 is a downstream component of the Sonic Hedgehog signaling pathway and functions mostly as a transcriptional repressor. GLI3 is required for the proper development of dorsal forebrain, ... -
The role of transaction costs in strengthening agricultural market linkages to achieve higher welfare in Tanzania
(2023-11-24)Small-scale farmers (SSFs) have high levels of food insecurity and poor nutrition that are reflections of the still high prevalent poverty rates. Semi-subsistence smallholder farming is still predominant in many parts of ... -
The role of Trim71 in cell fate determination of embryonic stem cells and germline development
(2015-12-22)The formation of complex tissues and organs from a limited set of stem and progenitor cells requires precise regulation of the balance between stem cell maintenance and differentiation. In the present study we introduce ... -
The Role of TRIM71 in Male Germ Cell Development
(2020-09-02)Germ cells are the key to continuation of life as they are the unique cell lineage capable to transfer the complete genetic information to the next generation. Both, infertility and testicular cancers are usually originating ... -
The Role of Whole Bone Marrow Cells in Scar Formation after Reperfusion of Myocardial Infarction in a Mouse Model
(2013-07-18)Koronare Herzkrankheit und Myokardinfarkt sind assoziiert mit signifikanter Morbidität und Mortalität. Eine frühe Reperfusion des Myokardinfarkts wird therapeutisch angestrebt, aber der nachfolgende Gewebeumbau geht mit ... -
The role of YAP signaling in thermogenic adiposetissues
(2021-01-02)One of major metabolic organs, brown adipose tissue (BAT), is responsible for energy expenditure through uncoupling protein 1 (UCP1) mediated non-shivering thermogenesis, which has been considered a promising pharmacological ... -
The roles of nutrition-sensitive interventions and market access in enhancing household food security and resilience in Sierra Leone
(2021-05-17)Using Sierra Leone – a post-conflict country in West Africa – as a case study, this dissertation addresses pressing issues on how to make smallholder agriculture more nutrition-sensitive, mitigate the adverse effects of ... -
Die Rolle der Aktin-Regulation durch die Proteine Cofilin 1 und Profilin 1 für die Entwicklung von T-Zellen
(2016-12-01)Die Regulation des Aktin-Zytoskeletts ist von entscheidender Bedeutung für die Entwicklung und Funktion von Zellen. Trotz intensiver Forschung an den Regulationsmechanismen, die den Auf- und Abbau von Aktinfilamenten ...
