E-Dissertationen: Browsing E-Dissertationen by Title
Now showing items 3164-3183 of 4089
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The role of the cannabinoid receptor 2 in alcohol-induced neuroinflammation and alcohol addiction
Pradier, Bruno (2015-02-11)Chronic alcohol abuse leads to severe brain damage, which has been associated with alcohol-induced neuroinflammation. Recently, the cannabinoid receptor 2 (CB<sub>2</sub>), which is predominantly expressed on immune cells, ... -
Role of the cannabinoid receptor 2 in the development of surgical neuropathic pain
Nent, Elisa (2018-12-12)When normal nociceptive pain becomes chronic, it loses its protective function and causes a general pain hypersensitivity. Neuropathic pain is one type of chronic pain, which is caused by various diseases or physical injury ... -
The role of the cannabinoid receptor 2 in the modulation of neuropathic pain
Klauke, Anna-Lena (2013-11-19)Neuropathic pain is a debilitating, chronic pain condition associated with inflammation or injury of peripheral and central nerves (Milligan and Watkins, 2009). The existing pharmacotherapies either lead to an inadequate ... -
The role of the CC chemokine CCL17 in a mouse model of Alzheimer’s disease
Neitzert, Kim Anke (2013-07-25)In Alzheimer's disease (AD), inflammatory processes are critically involved by cells releasing neurotoxic or neurotrophic factors influencing survival of neurons and synapses, and thereby cognitive behavior. Several ... -
The role of the chemokine receptor CXCR3 in mouse models for IL-12-driven CNS-inflammation and Morbus Alzheimer-like neurodegeneration
Krauthausen, Marius (2013-01-31)The chemokine receptor CXCR3 and its corresponding ligands CXCL9, CXCL10 and CXCL11 are well known to be involved in the trafficking and migration of activated CD4<sup>+</sup> Th1 T cells, CD8<sup>+</sup> T cells and NK ... -
The role of the endocannabinoid receptor CB2 in a mouse model of Alzheimer's disease
Lundt, Ramona (2018-09-26)Over the past years, an important role of the cannabinoid receptor 2 (CB2) has been implicated in several neurological and immunological conditions, such as experimental autoimmune encephalitis, stroke, memory, neuropathic ... -
The role of the endocannabinoid system in stress-related disorders and neuroimmune communication
Beins, Eva Carolina (2020-05-04)In the last decades, increasing evidence suggests that inflammatory processes play an important role in the development of psychiatric disorders, such as anxiety and depression. Psychosocial stress – one of the main ... -
The role of the Hippo pathway in etiology and progression of pancreato-biliary tumors and clear cell renal cell carcinoma
Schütte, Ute Theodora Gesina (2016-01-21)In the quest for the discovery of novel targets for cancer therapy, aberrantly reactivated embryonic signaling pathways have proven to be a rich mine and recent years have seen the introduction of the hedgehog-inhibitor ... -
The role of the miR-17-92 cluster in macrophage driven innate immunity
Stunden, H. James (2018-12-11)Research into miRNA, discovered in 1993, has exploded and revolutionized our understanding of molecular regulation in biological systems. MicroRNAs are now a well established as a regu- latory mechanism of many pathways ... -
Role of the proton channel HVCN1 in the regulation of neutrophil activation
Offermann, Nina (2023-06-22)(noch nicht zugänglich / not yet accessible) -
Role of the Receptor for Advanced Glycation End-products (RAGE) in the Immune Sensing of Nucleic Acids
Bertheloot, Damien (2016-09-06)Nucleic acid recognition is an important mechanism that enables the innate immune system to detect both microbial infection and tissue damage. To minimize the recognition of self-derived nucleic acids, all nucleic acid ... -
The role of the salvage pathway of phytol, geranylgeraniol, and farnesol phosphorylation in Arabidopsis thaliana
Romer, Jill (2021-03-09)The isoprenoid alcohol phytol can be phosphorylated in Arabidopsis to phytyl-phosphate (phytyl-P) by the phytol kinase (VTE5) and further to phytyl-diphosphate (phytyl-PP) by the phytyl phosphate kinase (VTE6). Phytyl-PP ... -
The role of the stemness factor Nanog in cell cycle regulation
Münst, Bernhard (2011-01-12)Pluripotency of embryonic stem (ES) cells is maintained through various extrinsic and intrinsic influences. In the center of intrinsic stemness signaling, a triad of transcription factors, namely Nanog, Oct3/4 and Sox2, ... -
The role of the transcription factor BCL11A in midbrain dopaminergic neurons
Tolve, Marianna (2022-03-11)Midbrain dopaminergic (mDA) neurons are located in three midbrain nuclei, the substantia nigra (SN), ventral tegmental area (VTA) and retrorubral field (RRF). mDA neurons are diverse in their developmental origin, their ... -
The role of the zinc finger transcription factor Gli3 in murine hindbrain development
Martínez Chávez, Erick Ariel (2019-07-15)The zinc finger transcription factor GLI3 is a downstream component of the Sonic Hedgehog signaling pathway and functions mostly as a transcriptional repressor. GLI3 is required for the proper development of dorsal forebrain, ... -
The role of Trim71 in cell fate determination of embryonic stem cells and germline development
Mitschka, Sibylle (2015-12-22)The formation of complex tissues and organs from a limited set of stem and progenitor cells requires precise regulation of the balance between stem cell maintenance and differentiation. In the present study we introduce ... -
The Role of TRIM71 in Male Germ Cell Development
Port, Yasmine (2020-09-02)Germ cells are the key to continuation of life as they are the unique cell lineage capable to transfer the complete genetic information to the next generation. Both, infertility and testicular cancers are usually originating ... -
The role of YAP signaling in thermogenic adiposetissues
Yang, Juhee (2021-01-02)One of major metabolic organs, brown adipose tissue (BAT), is responsible for energy expenditure through uncoupling protein 1 (UCP1) mediated non-shivering thermogenesis, which has been considered a promising pharmacological ... -
Die Rolle der Aktin-Regulation durch die Proteine Cofilin 1 und Profilin 1 für die Entwicklung von T-Zellen
Salz, Andrée Patrick (2016-12-01)Die Regulation des Aktin-Zytoskeletts ist von entscheidender Bedeutung für die Entwicklung und Funktion von Zellen. Trotz intensiver Forschung an den Regulationsmechanismen, die den Auf- und Abbau von Aktinfilamenten ... -
Rolle der Aktivierung des Peroxisome proliferator-activated receptor gamma durch Pioglitazon in der hepatischen Immunregulation
Schulte, Rike (2012-02-17)Der <em>Peroxisome proliferator-activated receptor gamma</em> (PPARγ) gehört zur Superfamilie nukleärer Faktoren, die nach Ligandenbindung Genexpression regulieren. PPARγ steuert durch Bindung an PPARγ-responsive Elemente ...