E-Dissertationen: Browsing E-Dissertationen by Title
Now showing items 795-814 of 4168
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Design, synthesis and optimization of receptor ligands: tools for studying purine-activated and related orphan G protein-coupled receptors
Harms, Tim (2022-04-01)<strong>Adenosine receptors</strong> <br /> The A<sub>2A</sub> and A<sub>2B</sub> adenosine receptors (ARs) are promising drug targets in Alzheimer´s and Parkinson´s disease, inflammatory diseases, autoimmune diseases, ... -
Design, synthesis and pharmacological evaluation of nucleotidic and non-nucleotidic inhibitors and probes for the ecto-5'-nucleotidase (CD73)
Rolshoven, Georg Wilhelm (2022-03-22)Ecto-5'-nucleotidase (CD73) plays a central role in the metabolic breakdown of extracellular AMP. The enzyme is attached to the cell membrane by a glycosylphosphatidylinositol anchor, but can also be released by shedding, ... -
Design, Synthesis and Structure-Activity-Relationships of Potent Mas-Related G Protein-Coupled Receptor X (MRGPRX) Modulators
Marx, Daniel (2021-04-12)The G protein-coupled receptor (GPCR) superfamily with more than 800 members is one of the most important target classes for drug development. After an agonist binds to the receptor, it induces a conformational change ... -
A detailed investigation of clear cell renal cell carcinoma cell and organoid cultures to find putative therapeutic targets and novel therapy approaches
Eßer, Laura Kristin (2022-06-20)Therapy options for metastasized renal cell carcinoma are limited. While immune checkpoint inhibitors and therapies targeting the tumor microenvironment have drastically changed treatment options, response rates are hardly ... -
A Detailed Study of Galaxy Clusters with Weak Gravitational Lensing and X-rays
Piel, Jennifer Miriam (2012-07-17)Galaxy clusters represent the top of hierarchical structure formation with the largest dark matter halos. Their abundance with respect to mass and redshift can be used to constrain cosmological parameters. The most extensive ... -
Detailed X-ray properties of galaxy groups and fossil groups
Vijaysarathy, Bharadwaj (2015-09-16)Most galaxies in the Universe are aggregated into groups of galaxies, agglomerations of a few 10s of galaxies at most. For long they have been considered to be very similar to clusters, which contain a few 100s of galaxies. ... -
Details of the immune response and impact of the microbiome in murine calcific aortic valve stenosis
Rodrigo, Maria Belen (2023-06-26)(noch nicht zugänglich / not yet accessible) -
Detecting Plant Functional Traits of Grassland Vegetation Using Spectral Reflectance Measurements
Hollberg, Jens Lothar (2018-03-06)Changes in climate and an intensified agricultural use threaten grassland ecosystems in many places. To allow an efficient conservation of grassland vegetation communities, ecologists monitor variations in their plant ... -
Detection and quantification of permafrost change in alpine rock walls and implications for rock instability
Krautblatter, Michael (2010-01-08)The perennial presence of ice in permafrost rock walls alters thermal, hydraulic and mechanic properties of the rock mass. Temperature-related changes in both, rock mechanical properties (compressive and tensile strength ... -
Detection and Simulation of Dangerous Human Crowd Behavior
Krausz, Barbara (2013-01-09)Tragically, gatherings of large human crowds quite often end in crowd disasters such as the recent catastrophe at the Loveparade 2010. In the past, research on pedestrian and crowd dynamics focused on simulation of pedestrian ... -
Detection of Legionella pneumophila and Pseudomonas aeruginosa and biofilm experiments in four different cooling towers (construction and biocide treatment) and evaluation of IDEXX most probable number methods in industrial water samples
Spies, Kirsten (2021-11-30)The responsible maintenance of evaporative cooling systems is an essential element in reducing the risk of the environmental dispersion of legionellae and Legionnaires’ disease outbreaks. In Germany, the 42nd Ordinance ... -
Detection of bacterial contaminations in platelet concentrates using Raman spectroscopy and flow cytometry
Schreiner, Manuel (2023-10-17)(noch nicht zugänglich / not yet accessible) -
Detection of Superparticles Beyond the Standard Model
Bornhauser, Sascha (2008)<p>This Phd thesis deals with supersymmetric particles within the context of astroparticle and collider physics.<br /> The first part is about the detection of UHE cosmic particles; it based on the use of the matter of ... -
Detection of Unknown Cyber Attacks Using Convolution Kernels Over Attributed Language Models
Duessel, Patrick (2018-07-05)Over the past decade the Internet has emerged as a key communication platform for businesses and private users demonstrated by an exponential increase of hosts connected to the Internet as well as Internet users. In light ... -
Detector Optimization Studies and Light Higgs Decay into Muons at CLIC
Grefe, Christian (2013-09-27)The Compact Linear Collider (CLIC) is a concept for a future e<sup>+</sup>e<sup>-</sup> linear collider with a center-of-mass energy of up to 3 TeV. The design of a CLIC experiment is driven by the requirements related to ... -
Detektion chromosomaler Kopienzahlveränderungen bei Patienten mit Intelligenzminderung zur Identifizierung und Charakterisierung von Kandidatengenen
Zink, Alexander Michael (2013-03-22)Die phänotypischen Unterschiede zwischen Individuen sind neben Umwelteinflüssen vor allem auf die genetische Variabilität zurückzuführen (Schafer & Hawkins, 1998). Das Spektrum bekannter genetischer Unterschiede zwischen ... -
Detektion diabetischer Stoffwechselentgleisungen bei forensischen Fragestellungen
Heß, Cornelius (2013-11-08)<p>Folgen einer Diabeteserkrankung sind die siebthäufigste Todesursache der Welt. Stoffwechselentgleisungen bei Lebenden sind außergewöhnlich häufig zu verzeichnen und stellen z.B. bei der aktiven Teilnahme am Straßenverkehr ... -
Detektion und Charakterisierung subtelomerischer Chromosomenaberrationen bei Patienten mit mentaler Retardierung unklarer Genese durch Multicolour-FISH
Ehrbrecht, Antje Carolin (2004)Mentale Retardierung (MR) betrifft etwa 3% der Bevölkerung, in 40-60% ist ihre Ursache unbekannt. Neben zahlreichen endo- und exogenen Faktoren spielen numerische und struturelle Chromosomenstörungen eine entscheidende ... -
Determination of adsorption and activation volumes and apparent transfer coefficients by pressure and potential modulation
Wang, Hanchun (2010-04-28)In this thesis the following investigations were carried out on Pt or Pt based electrodes: the determination of the apparent transfer coefficient (α′) for CO oxidation using an ac method, the determination of the molar ... -
Determination of spatial and temporal water relations in single leaves and canopies based on thermographic measurements
Albrecht, Hendrik (2016-11-28)Land plants are exposed to an exceptional challenge, because they need to take up CO<sub>2</sub> from a dry atmosphere, which induces water loss while taking up CO<sub>2</sub>. As the leaf water content (LWC) is a result ...