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Influence of the St. John's Wort Extract Ze117 on the Lipidome of PBMC and on the Lateral Diffusion of ß1-Adrenergic Receptors in C6 Cells
(2021-03-18)
Stress causes pathological changes in the signal transduction of neurotransmitter systems, which can lead to depression. Signaling relies not only on receptor-ligand interactions and subsequent regulatory processes, but ...
Diversity of regulatory systems and their contribution to colistin and tigecycline resistance in Acinetobacter baumannii
(2021-12-06)
Acinetobacter baumannii is a nosocomial pathogen which causes a wide range of serious infections in critically ill patients in the intensive care unit. Besides its high desiccation tolerance, the ability to form biofilms, ......
Effect of osmotic stress on barley leaf cuticles
(2021-07-19)
Assessing the drought stress tolerance at the seedling stage is an important trait as it later affects the growth and grain yield. The leaf and root characteristics are mainly focused on during this seedling stage. The ...
Metabarcoding Invertebrate Communities in a Natural Park: From Methods to Diversity Patterns
(2021-02-22)
Biodiversity is worldwide suffering from a dramatic decline, whose underlying causes are still fairly unknown. The scientific investigation and identification of potential drivers of biodiversity loss are strongly hampered ...
Characterization of small molecule inhibitors of the NLRP3 inflammasome
(2021-08-04)
To respond quickly to infection, the innate immune system contains many germline encoded pattern recognition receptors (PRRs) that recognize a myriad of danger signals released by pathogens and damaged tissues. NLRP3 ...
GPR183 Expression on Pulmonary Conventional Dendritic Cell Type 2 Dictates Subtissular Localisation and Instructs Their Survival via the Thymic Stromal Lymphopoietin (TSLP) – TSLP Receptor (TSLPR) Axis
(2021-07-06)
Introduction: G protein-coupled receptor 183 (GPR183) is a chemotactic receptor, highly expressed by immune cells. Upon activation by its ligand, 7a,25-dihydroxycholesterol (7a,25-OHC), GPR183 activates downstream signals ......
Analyse der intranukleären Dynamik und des Exports der ribosomalen 60S-Untereinheit
(2021-09-13)
Die Proteinbiosynthese wird von Ribosomen - großen molekularen Maschinen - durchgeführt, die aus zahlreichen verschiedenen Proteinen und einem ribosomalen RNA-Rückgrat bestehen. Die Biogenese der ribosomalen Untereinheiten ...
Low Endotoxin Recovery: Wiederfindung und pyrogene Aktivität von Endotoxinen in pharmazeutischen Produkten
(2021-08-06)
Eine zuverlässige Überwachung bakterieller Kontaminationen ist entscheidend für die Herstellung und Sicherheit biopharmazeutischer Produkte. Die mikrobielle Sicherheit wird in der Regel (zusätzlich zu Sterilitätstests und ...
Advanced migration assays for studying chemotaxis of slow moving cells
(2021-12-16)
Chemotaxis of slow moving cells plays a crucial role in numerous physiological and pathophysiological processes; including tumour metastasis, development, and wound healing. Therefore, a comprehensive understanding of ...
Exploration of bioresources enables detection and characterization of natural products with antibacterial activities and elucidation of the corresponding biosyntheses for derivative generation
(2021-11-17)
The discovery of antibiotics in the early 20th century sparked a medicinal revolution, which for the first time in history enabled humankind to effectively combat bacterial infections. Despite this immense success, the ...